You are running a travel clinic with your pharmacy and as an independent prescriber you can write prescriptions for malarial prophylaxis. Within your clinic, you use the maximum recommended treatment length for all courses. A family of two are travelling to Ghana for 14 days. The most recent weights of the family members are shown below.Mum: 54kgChild 1: 27kgBelow are the prices that you charge each of the drugs that are suitable for this family. They can either all take Lariam or the Malarone/Malarone PaediatricLariam tabs £14.48 per pack (8 tablets)Malarone £25.20 per pack (12 tablets)Malarone Paediatric £6.24 per pack (12 tablets)Using the information available to you and the relevant SPC (at the end of the worksheet), calculate the price difference between the two regimens. (Give your answer to the nearest pound) (Lariam 250 mg tablets)Active ingredient -mefloquine hydrochlorideLegal Category - POM: Prescription only medicine4.2 Posology and method of administrationChemoprophylaxisFor malaria prophylaxis the stated dose of Lariam should be given once weekly, always on the same day.In order to ensure, before arrival in endemic area, that Lariam administration is well tolerated, it is recommended to start chemoprophylaxis with Lariam 10 days before departure (i.e. first intake 10 days before departure and 2nd intake 3 days before departure). Subsequent doses should be taken once a week (on a fixed day).Treatment should be continued for 4 weeks after leaving a malarious area (minimum treatment period 6 weeks). The maximum recommended duration of administration of Lariam is 12 months.The recommended chemoprophylactic dose of Lariam is approximately 5 mg/kg bodyweight once weekly. The following dosage schedule is given as a guide: Adults and children of more than 45 kg bodyweight 1 tabletChildren and adults weighing less than 45 kg5 – 19 kg ¼ tablet 1/ 4 tablet20 – 30 kg ½ tablet 1/ 4 tablet31 – 45 kg ¾ tablet 3/ 4 tabletThe tablets should be swallowed whole preferably after a meal with plenty of liquid Malarone Paediatric Tablets4.2 Posology and method of administrationMethod of administrationThe daily dose should be taken once daily with food or amilky drink (to ensure maximum absorption) at the sametime each day.If patients are unable to tolerate food Malaronepaediatric tablets should be administered, but systemicexposure of atovaquone will be reduced. In the event ofvomiting within 1-hour of dosing a repeat dose shouldbe taken.Malarone paediatric tablets should preferably beswallowed whole. If difficulties are encountered whendosing young children, the tablets may be crushed andmixed with food or a milky drink just prior toadministration.PosologyThe dosage for the prophylaxis and treatment of acute,uncomplicated P. falciparum malaria in children is basedon body weight.ProphylaxisDosage in individuals weighing 11-40 kgDosage/dayNo of TabletsBody WeightRange (kg)Atovaquone(mg)Proguanil(mg)One Malarone paediatric tabletTwo Malarone paediatric tabletsThree Malarone paediatric tabletSubjects of >40 kg should receive ONE Malarone250/100 mg tablet dailyRefer to Malarone 250/100 mg Tablets SMPC11-2062.52521-301255031-40187.575>40250100Prophylaxis should• commence 24 or 48 hours prior to entering a malaria-endemic area,continue during the period of the stay,• continue for 7 days after leaving the area. Malarone4.2 Posology and method of administrationMethod of administrationThe daily dose should be taken with food or a milkydrink (to ensure maximum absorption) at the same timeeach day.If patients are unable to tolerate food, Malarone shouldbe administered, but systemic exposure of atovaquonewill be reduced. In the event of vomiting within 1 hour ofdosing a repeat dose should be taken.Posology.Prophylaxis:Prophylaxis should• commence 24 or 48 hours prior to entering a malaria-endemic area,• continue during the period of the stay• continue for 7 days after leaving the area.In residents (semi-immune subjects) of endemic areas,the safety and effectiveness of Malarone has beenestablished in studies of up to 12 weeks.In non-immune subjects, the average duration ofexposure in clinical studies was 27 days.Dosage in AdultsOne Malarone tablet daily.Malarone tablets are not recommended for malariaprophylaxis in persons under 40 kg bodyweight.Malarone paediatric tablets are recommended formalaria prophylaxis in persons weighing <40 kg

Solution- A family traveling to Ghana for = 14 days Weight of family members- Mum= 54 kgs.…

You are running a travel clinic with your pharmacy and as an independent prescriber you can write prescriptions for malarial prophylaxis. Within your clinic, you use the maximum recommended treatment length for all courses. A family of two are travelling to Ghana for 14 days. The most recent weights of the family members are shown below. Mum: 54kg Child 1: 27kg Below are the prices that you charge each of the drugs that are suitable for this family. They can either all take Lariam or the Malarone/Malarone Paediatric Lariam tabs £14.48 per pack (8 tablets) Malarone £25.20 per pack (12 tablets) Malarone Paediatric £6.24 per pack (12 tablets) Using the information available to you and the relevant SPC (at the end of the worksheet), calculate the price difference between the two regimens. (Give your answer to the nearest pound) (Lariam 250 mg tablets) Active ingredient -mefloquine hydrochloride Legal Category - POM: Prescription only medicine 4.2 Posology and method of administration Chemoprophylaxis For malaria prophylaxis the stated dose of Lariam should be given once weekly, always on the same day. In order to ensure, before arrival in endemic area, that Lariam administration is well tolerated, it is recommended to start chemoprophylaxis with Lariam 10 days before departure (i.e. first intake 10 days before departure and 2nd intake 3 days before departure). Subsequent doses should be taken once a week (on a fixed day). Treatment should be continued for 4 weeks after leaving a malarious area (minimum treatment period 6 weeks). The maximum recommended duration of administration of Lariam is 12 months. The recommended chemoprophylactic dose of Lariam is approximately 5 mg/kg bodyweight once weekly. The following dosage schedule is given as a guide: Adults and children of more than 45 kg bodyweight 1 tablet Children and adults weighing less than 45 kg 5 – 19 kg ¼ tablet 1/ 4 tablet 20 – 30 kg ½ tablet 1/ 4 tablet 31 – 45 kg ¾ tablet 3/ 4 tablet The tablets should be swallowed whole preferably after a meal with plenty of liquid