You are asked to design a continuous sterilizer to produce 330,000 L/d of sterile media. The system must operate for 30 days with the probability of failure to be 0.001. The initial concentration of spores in the medium is 104/1. The value of kd is 1 min-1 at 121°C and 60 min- 1 at 140°C. a. Estimate the residence time in the sterilizer at 121°C necessary to achieve the desired probability of success. b. Estimate the residence time required at 140°C. c. What is the ratio of residence times for high temperature, short-time sterilization to operation at 121°C?
You are asked to design a continuous sterilizer to produce 330,000 L/d of sterile media. The system must operate for 30 days with the probability of failure to be 0.001. The initial concentration of spores in the medium is 104/1. The value of kd is 1 min-1 at 121°C and 60 min- 1 at 140°C. a. Estimate the residence time in the sterilizer at 121°C necessary to achieve the desired probability of success. b. Estimate the residence time required at 140°C. c. What is the ratio of residence times for high temperature, short-time sterilization to operation at 121°C?
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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Transcribed Image Text:You are asked to design a continuous sterilizer to
produce 330,000 L/d of sterile media. The system must
operate for 30 days with the probability of failure to be
0.001. The initial concentration of spores in the medium
is 104/1. The value of kd is 1 min-1 at 121°C and 60 min-
1 at 140°C.
a. Estimate the residence time in the sterilizer at
121°C necessary to achieve the desired probability of
success.
b. Estimate the residence time required at 140°c.
c. What is the ratio of residence times for high temperature,
short-time sterilization to operation at
121°C?
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