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Write the detailed mechanisms for the following transformations.

Write the detailed mechanisms for the following transformations.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Write the detailed mechanisms for the following transformations.

### Reaction 3: - **Starting Material**: An indole derivative with a carbonyl group attached to a benzene ring. - **Reagents and Conditions**: - Concentrated hydrochloric acid (HCl) in dioxane as a solvent. - Reaction is conducted under reflux for 4 hours. - **Product**: A bicyclic compound featuring a fused five-membered ring with an indole structure. - **Yield**: 55% ### Reaction 4: - **Starting Material**: A methoxy-substituted aromatic compound with hydroxyl and silyl-protected groups. - **Reagents and Conditions**: - Boron trifluoride diethyl etherate (BF₃·OEt₂), used in 2 equivalents. - Reaction conducted in tetrahydrofuran (THF) at room temperature for 1 hour. - **Product**: An aromatic aldehyde derived from the starting compound with specific methoxy substitutions and one aldehyde group. - **Yield**: 68% - **Note**: R = TBDMS (tert-butyldimethylsilyl protecting group) These reactions illustrate transformations involving indole derivatives and methoxy-substituted aromatics, often found in organic synthesis studies.
Transcribed Image Text:### Reaction 3: - **Starting Material**: An indole derivative with a carbonyl group attached to a benzene ring. - **Reagents and Conditions**: - Concentrated hydrochloric acid (HCl) in dioxane as a solvent. - Reaction is conducted under reflux for 4 hours. - **Product**: A bicyclic compound featuring a fused five-membered ring with an indole structure. - **Yield**: 55% ### Reaction 4: - **Starting Material**: A methoxy-substituted aromatic compound with hydroxyl and silyl-protected groups. - **Reagents and Conditions**: - Boron trifluoride diethyl etherate (BF₃·OEt₂), used in 2 equivalents. - Reaction conducted in tetrahydrofuran (THF) at room temperature for 1 hour. - **Product**: An aromatic aldehyde derived from the starting compound with specific methoxy substitutions and one aldehyde group. - **Yield**: 68% - **Note**: R = TBDMS (tert-butyldimethylsilyl protecting group) These reactions illustrate transformations involving indole derivatives and methoxy-substituted aromatics, often found in organic synthesis studies.
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