Write the detailed mechanisms for the following transformations. ### Reaction 3:- **Starting Material**: An indole derivative with a carbonyl group attached to a benzene ring.- **Reagents and Conditions**: - Concentrated hydrochloric acid (HCl) in dioxane as a solvent. - Reaction is conducted under reflux for 4 hours.- **Product**: A bicyclic compound featuring a fused five-membered ring with an indole structure.- **Yield**: 55%### Reaction 4:- **Starting Material**: A methoxy-substituted aromatic compound with hydroxyl and silyl-protected groups.- **Reagents and Conditions**: - Boron trifluoride diethyl etherate (BF₃·OEt₂), used in 2 equivalents. - Reaction conducted in tetrahydrofuran (THF) at room temperature for 1 hour.- **Product**: An aromatic aldehyde derived from the starting compound with specific methoxy substitutions and one aldehyde group.- **Yield**: 68%- **Note**: R = TBDMS (tert-butyldimethylsilyl protecting group)These reactions illustrate transformations involving indole derivatives and methoxy-substituted aromatics, often found in organic synthesis studies.

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Chemistry

Write the detailed mechanisms for the following transformations.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

Write the detailed mechanisms for the following transformations.

### Reaction 3:

- **Starting Material**: An indole derivative with a carbonyl group attached to a benzene ring.
- **Reagents and Conditions**:
- Concentrated hydrochloric acid (HCl) in dioxane as a solvent.
- Reaction is conducted under reflux for 4 hours.
- **Product**: A bicyclic compound featuring a fused five-membered ring with an indole structure.
- **Yield**: 55%

### Reaction 4:

- **Starting Material**: A methoxy-substituted aromatic compound with hydroxyl and silyl-protected groups.
- **Reagents and Conditions**:
- Boron trifluoride diethyl etherate (BF₃·OEt₂), used in 2 equivalents.
- Reaction conducted in tetrahydrofuran (THF) at room temperature for 1 hour.
- **Product**: An aromatic aldehyde derived from the starting compound with specific methoxy substitutions and one aldehyde group.
- **Yield**: 68%
- **Note**: R = TBDMS (tert-butyldimethylsilyl protecting group)

These reactions illustrate transformations involving indole derivatives and methoxy-substituted aromatics, often found in organic synthesis studies.

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