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Would you predict that the Claisen condensation reaction shown below would work as written? 1. LDA, –78 °C 2. MeO No Yes

Would you predict that the Claisen condensation reaction shown below would work as written? 1. LDA, –78 °C 2. MeO No Yes

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Claisen Condensation Reaction Analysis** Would you predict that the Claisen condensation reaction shown below would work as written? **Reaction Setup:** The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 1. Reagents: - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature) - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \] **Expected Product:** The product shown on the right is a β-keto ester: - A ring structure with a ketone and an ester group separated by one CH2 group. **Question:** - Options: - No - Yes Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
Transcribed Image Text:**Claisen Condensation Reaction Analysis** Would you predict that the Claisen condensation reaction shown below would work as written? **Reaction Setup:** The reaction starts with a cyclohexanone compound (a six-membered cyclic ketone) on the left. 1. Reagents: - **LDA, –78 °C** (Lithium diisopropylamide, a strong base, used at low temperature) - The second step introduces an ester with the structure: \[ \text{MeO} \overset{\text{O}}{\vert} \text{C} \text{CH}_2 \text{CH}_2 \text{CH}_3 \] **Expected Product:** The product shown on the right is a β-keto ester: - A ring structure with a ketone and an ester group separated by one CH2 group. **Question:** - Options: - No - Yes Select whether you think the Claisen condensation, with the steps and conditions provided, would successfully yield the expected β-keto ester product.
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