Homework Help is Here – Start Your Trial Now!
Science
Biology
wild type allele TSS agouti Wild-type expression Agouti dominant negative copy number variant loss of function viable yellow allele TSS Ectopic expression TSS IAP H gap 99⁹9⁹99 unmethylated CG sites The Agouti gene is a determinant of coat color in furry mammals such mice. The wild type allele is expressed in the skin in a pattern that leads to the production "agouti" fur (left drawing, above). The viable yellow allele has an insertion (IAP) upstream of the normal transcription start site (TSS). Depending on the methylation status of multiple CG dinucleotides within IAP, this insertion can initiate transcription from an abnormal location near the insertion site, with transcription reading through the Agouti gene at an elevated level and causing the production of yellow fur (right drawing, above). Drawing adapted from Paro et al. Introduction to Epigenetics, Springer, 2021. This is background information for questions 18 through 23. Wild-type expression Agouti Which of the following classifiers of mutation type would you assign to the viable yellow allele with unmethylated CG sites in IAP? Yellow

wild type allele TSS agouti Wild-type expression Agouti dominant negative copy number variant loss of function viable yellow allele TSS Ectopic expression TSS IAP H gap 99⁹9⁹99 unmethylated CG sites The Agouti gene is a determinant of coat color in furry mammals such mice. The wild type allele is expressed in the skin in a pattern that leads to the production "agouti" fur (left drawing, above). The viable yellow allele has an insertion (IAP) upstream of the normal transcription start site (TSS). Depending on the methylation status of multiple CG dinucleotides within IAP, this insertion can initiate transcription from an abnormal location near the insertion site, with transcription reading through the Agouti gene at an elevated level and causing the production of yellow fur (right drawing, above). Drawing adapted from Paro et al. Introduction to Epigenetics, Springer, 2021. This is background information for questions 18 through 23. Wild-type expression Agouti Which of the following classifiers of mutation type would you assign to the viable yellow allele with unmethylated CG sites in IAP? Yellow

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question

19

wild type allele TSS gap agouti dominant negative Wild-type expression Agouti copy number variant loss of function 99999 unmethylated CG sites The Agouti gene is a determinant of coat color in furry mammals such mice. The wild type allele is expressed in the skin in a pattern that leads to the production "agouti" fur (left drawing, above). The viable yellow allele has an insertion (IAP) upstream of the normal transcription start site (TSS). Depending on the methylation status of multiple CG dinucleotides within IAP, this insertion can initiate transcription from an abnormal location near the insertion site, with transcription reading through the Agouti gene at an elevated level and causing the production of yellow fur (right drawing, above). Drawing adapted from Paro et al. Introduction to Epigenetics, Springer, 2021. This is background information for questions 18 through 23. gain of function viable yellow allele TSS Ectopic expression TSS IAP Which of the following classifiers of mutation type would you assign to the viable yellow allele with unmethylated CG sites in IAP? Wild-type expression Agouti Yellow
Transcribed Image Text:wild type allele TSS gap agouti dominant negative Wild-type expression Agouti copy number variant loss of function 99999 unmethylated CG sites The Agouti gene is a determinant of coat color in furry mammals such mice. The wild type allele is expressed in the skin in a pattern that leads to the production "agouti" fur (left drawing, above). The viable yellow allele has an insertion (IAP) upstream of the normal transcription start site (TSS). Depending on the methylation status of multiple CG dinucleotides within IAP, this insertion can initiate transcription from an abnormal location near the insertion site, with transcription reading through the Agouti gene at an elevated level and causing the production of yellow fur (right drawing, above). Drawing adapted from Paro et al. Introduction to Epigenetics, Springer, 2021. This is background information for questions 18 through 23. gain of function viable yellow allele TSS Ectopic expression TSS IAP Which of the following classifiers of mutation type would you assign to the viable yellow allele with unmethylated CG sites in IAP? Wild-type expression Agouti Yellow
What fur color do you expect to observe in a heterozygote that has one wild type allele and one viable yellow allele with unmethylated CG sites in IAP? Yellow Agouti
Transcribed Image Text:What fur color do you expect to observe in a heterozygote that has one wild type allele and one viable yellow allele with unmethylated CG sites in IAP? Yellow Agouti
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Developmental biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS