Why is the name the "citrate cycle" a more accurate name for the metabolic pathway discovered by Hans Krebs than the "citric acid cycle"? The pKa values of the three carboxylate groups are all higher than pH 7, and therefore the COO- groups will be protonated and are not acids. The three carboxylate groups are protonated under physiological conditions, and therefore do not function as acids. The enzyme in the first reaction is called citrate synthetase, so it just makes sense to call the metabolic cycle the citrate cycle. The pka values of the three carboxylate groups are all lower than pH 7, and therefore the COO- groups will be deprotonated and are not acids.
Why is the name the "citrate cycle" a more accurate name for the metabolic pathway discovered by Hans Krebs than the "citric acid cycle"? The pKa values of the three carboxylate groups are all higher than pH 7, and therefore the COO- groups will be protonated and are not acids. The three carboxylate groups are protonated under physiological conditions, and therefore do not function as acids. The enzyme in the first reaction is called citrate synthetase, so it just makes sense to call the metabolic cycle the citrate cycle. The pka values of the three carboxylate groups are all lower than pH 7, and therefore the COO- groups will be deprotonated and are not acids.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
15
Transcribed Image Text:Why is the name the "citrate cycle" a more accurate name for the metabolic
pathway discovered by Hans Krebs than the "citric acid cycle"?
The pKa values of the three carboxylate groups are all higher than pH 7,
and therefore the COO- groups will be protonated and are not acids.
The three carboxylate groups are protonated under physiological
conditions, and therefore do not function as acids.
The enzyme in the first reaction is called citrate synthetase, so it just
makes sense to call the metabolic cycle the citrate cycle.
The pKa values of the three carboxylate groups are all lower than pH 7,
and therefore the COO- groups will be deprotonated and are not acids.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON