Why is proteasome degradation of poly-ubiquitylated proteins so energetically expensive? Unfoldase does not easily denature stable proteins with each round of ATP hydrolysis O The ubiquitin receptor in the proteasome cap requires multiple ATP units to bind to the substrate Attaching each ubiquitin requires the release of two phosphates from ATP E3 ubiquitin ligases require many rounds of ATP hydrolysis to transfer the ubiquitin to the substrate O Each ubiquitin has to be removed before the protein can be degraded

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