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Why is DNA testing used for a patient with sickle cell anemia?
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- What are the specific genetic tests used for Beta-Thalassemia?A couple is concerned their child will be born with sickle cell anemia. The woman does not have sickle cell anemia. The woman’s mother had sickle cell anemia and her father was a carrier of the sickle cell gene. The man knows that he is a carrier of the sickle cell gene. What is the probability that the child will have sickle cell anemia?Patient D died shortly after birth, with a multitude of anomalies, including microcephaly, low set malformed ears, bilateral harelip, cleft palate, and congenital heart defects. Chromosomes were obtained from a tissue sample. Identify Patient's D a) Number of chromosomes, b) Sex, c) Type of Aberration (if any), d) Type of Syndrome/Trisomy
- What does the acronym TPA stand for and how is TPA used in diagnostic medicine? Explain 2-3 sentencesExplain how PCR/OLA (polymerase chain reaction/oligonucleotide ligation assay) can be used in the diagnosis of sickle cell disorder . Would you recommend this method for routine diagnosis of sickle cell disorder? ExplainWhich is more proper sample type for whole genome sequencing in AML patients? Peripheral blood or bone marrow?
- What is the genotype of a normal man whose father had hemophilia?I understand that microarrays are being used to define the molecular abnormality and the prognosis in some patients with leukaemia. What are microarrays?What genes are involved in Gaucher disease? Is the sequence of the gene known? Is genetic testing recommended for Gaucher disease? Give typing answer with explanation and conclusion