Why does the addition of primary amines to aldehydes/ketones not work well at pH < 5? The amine gets protonated, making it no longer nucleophilic The -OH group can no longer be deprotonated to form a leaving group The amine gets deprotonated, making it no longer nucleophilic O The -OH group can no longer be protonated to form a leaving group

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Chapter1: Chemical Foundations
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Why does the addition of primary amines to aldehydes/ketones not work well at pH
< 5?
The amine gets protonated, making it no longer nucleophilic
The -OH group can no longer be deprotonated to form a leaving group
The amine gets deprotonated, making it no longer nucleophilic
The -OH group can no longer be protonated to form a leaving group
Transcribed Image Text:Why does the addition of primary amines to aldehydes/ketones not work well at pH < 5? The amine gets protonated, making it no longer nucleophilic The -OH group can no longer be deprotonated to form a leaving group The amine gets deprotonated, making it no longer nucleophilic The -OH group can no longer be protonated to form a leaving group
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