Why does histone deacetylase action tend to repress transcription?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Transcribed Image Text:Why does histone deacetylase action tend to repress transcription?
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Histones are the proteins responsible for DNA, providing structural integrity to the chromosomes, packaging into the cell, and regulation of genes. These are the basic proteins composed of positively charged amino acids including arginine and lysine that bind with the negatively charged DNA molecule and condenses into chromatin. Histone acetylation and deacetylation are epigenetic modifications that help in regulating gene expression.
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