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Why does complement only rarely kill host cells?

Why does complement only rarely kill host cells?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Why does complement only rarely kill host cells? Soluble RCAS, most act at or near C3 convertase amplification - Cl inhibitor: (causes C1r2s2 to dissociate from C1q) - Factor H (blocks formation of C3 convertase) - Factor I (cleaves C3b/C4b) - C4b binding protein (blocks C3 convertase formation) S protein: blocks C5b67 membrane insertion "bystander lysis" Membrane bound RCAS, all broadly impact the three complement pathways Complement receptor 1 (CR1): Blocks C3 convertase formation on host membranes Decay accelerating factor (DAF): Breaks apart C3 convertases Homologous restriction factor (HRF/MIRL): Blocks C9 binding to MAC
Transcribed Image Text:Why does complement only rarely kill host cells? Soluble RCAS, most act at or near C3 convertase amplification - Cl inhibitor: (causes C1r2s2 to dissociate from C1q) - Factor H (blocks formation of C3 convertase) - Factor I (cleaves C3b/C4b) - C4b binding protein (blocks C3 convertase formation) S protein: blocks C5b67 membrane insertion "bystander lysis" Membrane bound RCAS, all broadly impact the three complement pathways Complement receptor 1 (CR1): Blocks C3 convertase formation on host membranes Decay accelerating factor (DAF): Breaks apart C3 convertases Homologous restriction factor (HRF/MIRL): Blocks C9 binding to MAC
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