While recording intracellularly from a DS RGC, you drift a light spot first rightward, and then leftward, and observe that the light spot causes spiking during the leftward motion but not the rightward motion. Suppose you want to apply drugs so that the light spot would evoke spikes in both rightward and leftward directions. Which of the following would you apply? A cocktail of antagonists for ionotropic glutamate receptors. A cocktail of antagonists for ionotropic GABA receptors. A glycine receptor antagonist. Any of the above would work.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
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Chapter6: The Peripheral Nervous System: Afferent Division; Special Senses
Section: Chapter Questions
Problem 13RE
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Retinal Ganglion cell question, multiple choice!

 

Regarding the synaptic circuits of OFF DS RGCS and OFF starburst cells,
which of the statements below is correct? Hint: Both cell types receive input
in the OFF sublamina of the inner plexiform layer.
An OFF DS RGC's excitatory zone receives OFF bipolar cell input, whereas its
inhibitory zone receives OFF starburst cell input.
An OFF DS RGC's excitatory zone receives ON bipolar cell input, whereas its
inhibitory zone receives OFF starburst cell input.
An OFF starburst dendrite's excitatory zone receives ON bipolar cell input, whereas
its inhibitory zone receives input from another OFF starburst cell.
An OFF starburst dendrite's excitatory zone receives OFF bipolar cell input,
whereas its inhibitory zone receives input from another OFF starburst cell.
Two of the above are correct.
Transcribed Image Text:Regarding the synaptic circuits of OFF DS RGCS and OFF starburst cells, which of the statements below is correct? Hint: Both cell types receive input in the OFF sublamina of the inner plexiform layer. An OFF DS RGC's excitatory zone receives OFF bipolar cell input, whereas its inhibitory zone receives OFF starburst cell input. An OFF DS RGC's excitatory zone receives ON bipolar cell input, whereas its inhibitory zone receives OFF starburst cell input. An OFF starburst dendrite's excitatory zone receives ON bipolar cell input, whereas its inhibitory zone receives input from another OFF starburst cell. An OFF starburst dendrite's excitatory zone receives OFF bipolar cell input, whereas its inhibitory zone receives input from another OFF starburst cell. Two of the above are correct.
While recording intracellularly from a DS RGC, you drift a light spot first
rightward, and then leftward, and observe that the light spot causes spiking
during the leftward motion but not the rightward motion. Suppose you want
to apply drugs so that the light spot would evoke spikes in both rightward
and leftward directions. Which of the following would you apply?
A cocktail of antagonists for ionotropic glutamate receptors.
A cocktail of antagonists for ionotropic GABA receptors.
A glycine receptor antagonist.
O Any of the above would work.
Transcribed Image Text:While recording intracellularly from a DS RGC, you drift a light spot first rightward, and then leftward, and observe that the light spot causes spiking during the leftward motion but not the rightward motion. Suppose you want to apply drugs so that the light spot would evoke spikes in both rightward and leftward directions. Which of the following would you apply? A cocktail of antagonists for ionotropic glutamate receptors. A cocktail of antagonists for ionotropic GABA receptors. A glycine receptor antagonist. O Any of the above would work.
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