Which reactions in the first phase of glycolysis are exergonic at standard conditions? O hexokinase, phosphofructokinase O PFK O Hexokinase O all reactions are exergonic
Which reactions in the first phase of glycolysis are exergonic at standard conditions? O hexokinase, phosphofructokinase O PFK O Hexokinase O all reactions are exergonic
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Which reactions in the first phase of glycolysis are exergonic at standard conditions?
O hexokinase, phosphofructokinase
O PFK
O Hexokinase
O all reactions are exergonic
Transcribed Image Text:Use the following table for all questions in the problem set related to glycolysis:
TABLE 18.1 Reactions and Thermodynamics of Glycolysis
AG"
AG
Reaction
Enzyme
(k/mol)
at 25°c
(kJ/mol)
Hexokinase
Glucokinase
a-D-Glucose + ATPt-=
-16.7
850
-33.9*
glucose-6-phosphate?- + ADP- + H*
Glucose-6 phosphate²-=fructose-6-phosphate-
Fructose-6-phosphate- + ATP-=
fructose-1,6-bisphosphate- + ADP- + H*
Fructose-1,6-bisphosphate
dihydroxyacetone-P- + glyceraldehyde-3-P:-
Dihydroxyacetone-P=glyceraldehyde-3-P-
Glyceraldehyde-3-P- + P?- + NAD*=
1,3-bisphosphoglycerate- + NADH + H*
1,3-Bisphosphoglycerate + ADP-
Phosphoglucoisomerase
Phosphofructokinase
+1.67
0.51
-2.92
-14.2
310
-18.8
Fructose bisphosphate
aldolase
+23.9
6.43 X 10-3
-0.23
Triose phosphate isomerase
Glyceraldehyde-3-P
dehydrogenase
Phosphoglycerate kinase
+7.56
0.0472
+2.41
+6.30
0.0786
-1.29
-18.9
2060
+0.1
3-Pglycerate- + ATP-
3-Phosphoglycerate =2phosphoglycerate
2-Phosphoglycerate-=
Phosphoglycerate mutase
+4.4
0.169
+0.83
Enolase
+1.8
0.483
+1.1
phosphoenolpyruvate-+ H,0
Phosphoenolpyruvate- + ADP- + H* =
Pyruvate + ATpt-
Pyruvate + NADH + H*= lactate" + NAD*
Pyruvate kinase
-31.7
3.63 x 10
-23.0
Lactate dehydrogenase
-25.2
2.63 x 10
-14.8
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