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Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 3 COLLAI locus 179 COLIA2 locus missense mutation major mutation 79 曲 ABNORMAL EXPRESSION NO EXPRESSION EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1

Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 3 COLLAI locus 179 COLIA2 locus missense mutation major mutation 79 曲 ABNORMAL EXPRESSION NO EXPRESSION EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 major mutation missense COLIA1 locus 179 COLIA2 locus 79 mutation EXPRESSION ABNORMAL EXPRESSION NO EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains 18 normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1
Transcribed Image Text:Which of these scenarios will result in a severe phenotype of osteogenesis imperfecta and why? 1 2 major mutation missense COLIA1 locus 179 COLIA2 locus 79 mutation EXPRESSION ABNORMAL EXPRESSION NO EXPRESSION n chains n normal chains +n mutant chains n chains n chains 2n chains n chains 18 normal procollagen molecules S procollagen molecules n procollagen molecules (three chains) Page 1
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