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Which of these proteins contain IDRS, and how do the IDRS impact signaling?

Which of these proteins contain IDRS, and how do the IDRS impact signaling?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Signaling proteins, including protein kinases, often have intrinsically disordered regions (IDRS) that are important in signaling. The IDRS allow the signaling proteins to be multivalent, interacting with several different proteins in order to form a signaling complex. Which of these proteins contain IDRS, and how do the IDRS impact signaling? In neuronal signaling, IDRS regulate the opening and closing of voltage-gated K* channels. A kinase anchoring proteins (AKAPS) have multiple IDRS that act as distinct protein-binding domains. In the insulin signaling pathway, an IDR in the Ras protein regulates its ability to activate Raf-1. In the MAPK cascade, an amino-terminal IDR acts as a docking site in the multienzyme complex. O In the B-adrenergic pathway, an IDR in the carboxyl-terminal tail of protein kinase A regulates the enzyme's activity.
Transcribed Image Text:Signaling proteins, including protein kinases, often have intrinsically disordered regions (IDRS) that are important in signaling. The IDRS allow the signaling proteins to be multivalent, interacting with several different proteins in order to form a signaling complex. Which of these proteins contain IDRS, and how do the IDRS impact signaling? In neuronal signaling, IDRS regulate the opening and closing of voltage-gated K* channels. A kinase anchoring proteins (AKAPS) have multiple IDRS that act as distinct protein-binding domains. In the insulin signaling pathway, an IDR in the Ras protein regulates its ability to activate Raf-1. In the MAPK cascade, an amino-terminal IDR acts as a docking site in the multienzyme complex. O In the B-adrenergic pathway, an IDR in the carboxyl-terminal tail of protein kinase A regulates the enzyme's activity.
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