Which of the following statements about "Focused transcription initiation", "Dispersed transcription initiation" and "transcription start sites" (TSS) are correct.

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Which of the following statements
about "Focused transcription
initiation", "Dispersed transcription
initiation" and "transcription start sites"
(TSS) are correct.
Note: it's more than 1!
The majority of human genes is
regulated from dispersed promoters.
Focused initiation starts form a single or
narrow set of transcription start sites
(TSSS).
Focused and dispersed transcription
initiation refer to the extreme ends of a
continuum of initiation patterns.
Dispersed transcription initiation is the
evolutionary more ancient mechanism.
RNA-seq is the preferred method to
map TSS.
Although dispersed promoter start from
multiple TSS, the resulting transcripts
usually encode for the same protein.
Transcribed Image Text:Which of the following statements about "Focused transcription initiation", "Dispersed transcription initiation" and "transcription start sites" (TSS) are correct. Note: it's more than 1! The majority of human genes is regulated from dispersed promoters. Focused initiation starts form a single or narrow set of transcription start sites (TSSS). Focused and dispersed transcription initiation refer to the extreme ends of a continuum of initiation patterns. Dispersed transcription initiation is the evolutionary more ancient mechanism. RNA-seq is the preferred method to map TSS. Although dispersed promoter start from multiple TSS, the resulting transcripts usually encode for the same protein.
Which of the following statements
about "Focused transcription
initiation", "Dispersed transcription
initiation" and "transcription start sites"
(TSS) are correct.
Note: it's more than 1!
The majority of human genes is
regulated from dispersed promoters.
Focused initiation starts form a single or
narrow set of transcription start sites
(TSSS).
Focused and dispersed transcription
initiation refer to the extreme ends of a
continuum of initiation patterns.
O Dispersed transcription initiation is the
evolutionary more ancient mechanism.
RNA-seq is the preferred method to
map TSS.
Although dispersed promoter start from
multiple TSS, the resulting transcripts
usually encode for the same protein.
Transcribed Image Text:Which of the following statements about "Focused transcription initiation", "Dispersed transcription initiation" and "transcription start sites" (TSS) are correct. Note: it's more than 1! The majority of human genes is regulated from dispersed promoters. Focused initiation starts form a single or narrow set of transcription start sites (TSSS). Focused and dispersed transcription initiation refer to the extreme ends of a continuum of initiation patterns. O Dispersed transcription initiation is the evolutionary more ancient mechanism. RNA-seq is the preferred method to map TSS. Although dispersed promoter start from multiple TSS, the resulting transcripts usually encode for the same protein.
Expert Solution
Step 1: What is transcription ?

Transcription is the process by which the DNA sequence is "transcribed" into RNA sequence. It is the first step in gene regulation. Protein is what gives living organisms its form. The DNA has a lot of material, of which genes are a small part. These genes or protein coding regions alone are copied into RNA, which is then translated into proteins.

RNAs are of many types. mRNA or messenger RNA is the RNA, as the name suggests, carries the protein coding information from the DNA to the proteins.

Transcription involves the following steps:

  1. Initiation: Unwinding of DNA and binding of the RNA polymerase to the promoter
  2. Elongation: The RNA polymerase moves forwards generating the RNA strand
  3. Termination: This step varies between prokaryotes and eukaryotes. In eukaryotes, there is an additional step of adding a polyA tail
  4. Post transcriptional modifications: This includes splicing out the introns, addition of 5' G-cap

 

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