Which of the following statements about 2,3-bisphosphoglycerate (2,3-BPG) are TRUE. 2,3-BPG lowers the affinity of hemoglobin for oxygen. 2,3-BPG stabilizes the T-state of hemoglobin. 2,3-BPG has a lower affinity for HbF than for HbA. 2,3-BPG can diffuse out of the RBC in the lungs, in order to allow oxygen to bind to hemoglobin and stabilize the R state. 2,3-BPG lowers the affinity of myoglobin for oxygen.

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