Which of the following reaction schemes would make the alcohol hown below? Select any that apply. OH 0 0 & H + CH3MgBr CH3MgBr MgBr HMgBr 2) H₂0¹ 2) H30¹ 2) H30* 2) H30*

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Please help with the acetal/grignard reaction 

### Question 1

**Prompt:**

Which of the following reaction schemes would make the alcohol shown below? Select any that apply.

**Target Alcohol Structure:**

The structure shown is a six-membered cyclohexane ring with a hydroxyl group (OH) attached to it, as well as an adjacent methyl group.

**Reaction Schemes:**

1. **Option A:**
   - Reactants: Ketone (cyclohexanone) + CH₃MgBr (methylmagnesium bromide)
   - Conditions: H₃O⁺ (acidic work-up)
   - Outcome: Reacts to form the secondary alcohol shown.

2. **Option B:**
   - Reactants: Ketone (cyclopentanone with an additional methyl group) + CH₃MgBr
   - Conditions: H₃O⁺
   - No reaction forming the shown alcohol.

3. **Option C:**
   - Reactants: Formaldehyde (HCHO) + cyclohexylmagnesium bromide
   - Conditions: H₃O⁺
   - Outcome: Reacts but does not form the target alcohol.

4. **Option D:**
   - Reactants: Cyclohexanone + H-MgBr
   - Conditions: H₃O⁺
   - Outcome: This reaction forms the desired alcohol.

**Correct Options:**

- Option A
- Option D

These reactions correctly form the alcohol given in the prompt by utilizing a Grignard reagent in an addition reaction followed by an acidic work-up.
Transcribed Image Text:### Question 1 **Prompt:** Which of the following reaction schemes would make the alcohol shown below? Select any that apply. **Target Alcohol Structure:** The structure shown is a six-membered cyclohexane ring with a hydroxyl group (OH) attached to it, as well as an adjacent methyl group. **Reaction Schemes:** 1. **Option A:** - Reactants: Ketone (cyclohexanone) + CH₃MgBr (methylmagnesium bromide) - Conditions: H₃O⁺ (acidic work-up) - Outcome: Reacts to form the secondary alcohol shown. 2. **Option B:** - Reactants: Ketone (cyclopentanone with an additional methyl group) + CH₃MgBr - Conditions: H₃O⁺ - No reaction forming the shown alcohol. 3. **Option C:** - Reactants: Formaldehyde (HCHO) + cyclohexylmagnesium bromide - Conditions: H₃O⁺ - Outcome: Reacts but does not form the target alcohol. 4. **Option D:** - Reactants: Cyclohexanone + H-MgBr - Conditions: H₃O⁺ - Outcome: This reaction forms the desired alcohol. **Correct Options:** - Option A - Option D These reactions correctly form the alcohol given in the prompt by utilizing a Grignard reagent in an addition reaction followed by an acidic work-up.
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