Which of the following molecules has the most pro-inflammatory activity? TXA2 swer PGE2 ered PGI2
Why is this correct?
Prostaglandins are synthesized from arachidonic acid. Prostaglandin I2 (PGI2) or prostacyclin has anti-inflammatory activity. It is required for the action of the enzyme cyclooxygenase (cox). PGI2 or Prostacyclin acts as an antagonist of thromboxane A2. Prostaglandin I2 (PGI2) or prostacyclin (local hormones) are plays important roles in mediating inflammation, maintaining homeostasis, acts as a vasodilator and inhibitor of platelet aggregation.
Thromboxane (TXA2) is the most powerful vasoconstrictor while prostacyclin (PGI2) is a vasodilator. TXA2 synthesizes platelets. Whereas PGI2 is derived from the endothelium. TXA2 plays important role in blood clotting by stimulating platelet aggregation.
PGE2 is one of the most abundant prostaglandin (PGs) produced in the body and it is mainly responsible for inflammation. It results in the classic signs of inflammation: redness, swelling, and pain.
Prostaglandins mediate inflammation and pain, stimulate uterine contraction, lower blood pressure, and also act as vasodilators.
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