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Which of the following is the most reasonable explanation for why arsenate is detrimental to a cell's ability to produce ATP through glycolysis?

Which of the following is the most reasonable explanation for why arsenate is detrimental to a cell's ability to produce ATP through glycolysis?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Arsenate is structurally and chemically similar to inorganic phosphate (Pi), and many enzymes that require phosphate will also use arsenate. However, organic compounds of arsenate are less stable than analogous phosphate compounds, however. For example, acyl arsenates decompose rapidly by hydrolysis: R-C-0-As-O + H20 R-C-0 + HO-As-O + H* On the other hand, acyl phosphates, such as 1,3-bisphosphoglycerate, are more stable and undergo further enzyme- catalyzed transformation in cells. Which of the following is the most reasonable explanation for why arsenate is detrimental to a cell's ability to produce ATP through glycolysis? Arsenate inhibits all of the enzymes in glycolysis Arsenate causes reaction 7 of glycolysis to be bypassed The decomposition of acyl arsenates can lead to alkalosis Arsenate induces a higher activity of gluconeogenesis
Transcribed Image Text:Arsenate is structurally and chemically similar to inorganic phosphate (Pi), and many enzymes that require phosphate will also use arsenate. However, organic compounds of arsenate are less stable than analogous phosphate compounds, however. For example, acyl arsenates decompose rapidly by hydrolysis: R-C-0-As-O + H20 R-C-0 + HO-As-O + H* On the other hand, acyl phosphates, such as 1,3-bisphosphoglycerate, are more stable and undergo further enzyme- catalyzed transformation in cells. Which of the following is the most reasonable explanation for why arsenate is detrimental to a cell's ability to produce ATP through glycolysis? Arsenate inhibits all of the enzymes in glycolysis Arsenate causes reaction 7 of glycolysis to be bypassed The decomposition of acyl arsenates can lead to alkalosis Arsenate induces a higher activity of gluconeogenesis
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