Which is a FALSE statement about X inactivation in mammalian females?O Females that are heterozygous for an X-linked gene have patches of cells that express one allele and patches of cells that express the other.O Xinactivation is random as to which X is inactivated and takes place early in embryonic developmentInactivation is initiated by expression of the Xist gene on the X chromosome that will remain active.Once an X chromosome first becomes inactivated in a cell, that same X will remain inactivated in somatic cells that are descendants of this cell.DOOO

Name: Which is a FALSE statement about X inactivation in mammalian females?
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Description: Which is a FALSE statement about X inactivation in mammalian females?O Females that are heterozygous for an X-linked gene have patches of cells that express one allele and patches of cells that express the other.O Xinactivation is random as to which

X-chromosome inactivation is the transcriptional silencing of one X chromosome in female mammalian…

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Which is a FALSE statement about X inactivation in mammalian females? O Females that are heterozvaoLIs for an X-linked gene bave patches of cells that express one allele and patches of cells that expre

Which is a FALSE statement about X inactivation in mammalian females? O Females that are heterozvaoLIs for an X-linked gene bave patches of cells that express one allele and patches of cells that expre

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter7: Development And Sex Determination

Section: Chapter Questions

Problem 18QP: Equalizing the Expression of X Chromosome Genes in Males and Females Males have only one X...

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. In humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain how this incident happens and why will there be skewed X-inactivation?
Briefly describe the molecular processes that cause one X chromosome in each female cell to be active and the other X chromosome to be inactivated.
Following X-chromosome inactivation, most of the genes on theinactivated X chromosome are silenced. Explain how. Name onegene that is not silenced.
Equalizing the Expression of X Chromosome Genes in Males and Females Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?
Equalizing the Expression of X Chromosome Genes in Males and Females Males have only one X chromosome and therefore only one copy of all genes on the X chromosome. Each gene is directly expressed, thus providing the basis of hemizygosity in males. Females have two X chromosomes, but one is always inactivated. Therefore, females, like males, have only one functional copy of all the genes on the X chromosome. Again, each gene must be directly expressed. Why, then, are females not considered hemizygous, and why are they not afflicted with sex-linked recessive diseases as often as males are?
Almost all calico cats (one is pictured in FIGURE 10.7B) are female. Why? B When this calico cat was an embryo, one of the two X chromosomes was inactivated in each of her cells. The descendants of the cells formed her adult body, which is a mosaic for expression of X chromosome genes. Black fur arises in patches where genes on the X chromosome inherited from one parent are expressed; orange fur arises in patches where genes on the X chromosome inherited from the other parent are expressed. FIGURE 10.7 Animated X chromosome inactivation.
What is a Barr body? How is its structure different from that ofother chromosomes in the cell? How does the structure of a Barrbody affect the level of X-linked gene expression?
Why does X inactivation occur in female mammals?
In mammalian females, the majority of one X chromosome's genes are shut down in a process called X chromosome condensed and afterwards called a The inactive X is Because the shutdown is random in the embryonic cells formed by the time inactivation occurs, all mature mammalian females are a for the expression of X chromosome genes. The inactivation of one X in the female is thought to . The shutdown of the X chromosome is accomplished by the balance gene expression between males and females, a theory called gene. is the master gene for male sex determination in mammals and is found on the human Y-chromosome.
Describe when X-chromosome inactivation occurs and how thisleads to phenotypic results at the organism level. In your answer,you should explain why XCI causes results such as variegated coatpatterns in mammals. Why do two different calico cats have theirpatches of orange and black fur in different places? Explainwhether or not a variegated coat pattern due to XCI could occur inmarsupials.
In humans, hemophilia is an X-linked recessive gene and will only be expressed in females if they are homozygous for this gene. However, in some rare cases, a heterozygote becomes hemophilic. Explain how this incident happens.
Barr bodies are formed to adjust X chromosome dosage in species other than humans, such as Drosophila (fruit flies) and C. elegans (nematodes). True or False ?