Which chair represents the most stable conformation of Molecule A? a В с с D d E e Molecule A Me Me Me Me Chair conformations Me a) Me b) c) Me Me Me Me Me Me Me Me Me Me d) Me e) Me Me Ме Me- Ме Me Me A

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### Assessing the Most Stable Conformation of Molecule A

#### Question:
**Which chair represents the most stable conformation of Molecule A?**

- **A.** a
- **B.** b
- **C.** c
- **D.** d
- **E.** e * (Selected Answer)

#### Explanation:
Below the question and answer choices, there is a diagram labeled "Molecule A" which shows a chemical structure of a cyclohexane ring with multiple methyl groups (Me) attached at various carbon atoms.

Underneath the representation of Molecule A, there is another section titled "Chair conformations," where five different chair conformations of a substituted cyclohexane ring (labeled a, b, c, d, and e) are depicted.

Here, each conformation illustrates the spatial arrangement of methyl groups attached to the cyclohexane ring. The stability of these conformers can be assessed based on steric interactions and the positioning of bulky groups in equatorial vs. axial positions:

- **Conformation a:** One methyl group in the axial position, others in equatorial.
- **Conformation b:** Similar arrangement with axial and equatorial positioning.
- **Conformation c:** Methyl groups in various axial positions, increasing steric hindrance.
- **Conformation d:** Another varying arrangement of axial and equatorial methyl groups.
- **Conformation e:** Methyl groups predominantly in equatorial positions, which generally minimizes steric clashes compared to axial positions.

Thus, the selected answer E is considered to represent the most stable chair conformation of Molecule A, as it likely places the bulky methyl groups in positions that minimize steric strain.
Transcribed Image Text:### Assessing the Most Stable Conformation of Molecule A #### Question: **Which chair represents the most stable conformation of Molecule A?** - **A.** a - **B.** b - **C.** c - **D.** d - **E.** e * (Selected Answer) #### Explanation: Below the question and answer choices, there is a diagram labeled "Molecule A" which shows a chemical structure of a cyclohexane ring with multiple methyl groups (Me) attached at various carbon atoms. Underneath the representation of Molecule A, there is another section titled "Chair conformations," where five different chair conformations of a substituted cyclohexane ring (labeled a, b, c, d, and e) are depicted. Here, each conformation illustrates the spatial arrangement of methyl groups attached to the cyclohexane ring. The stability of these conformers can be assessed based on steric interactions and the positioning of bulky groups in equatorial vs. axial positions: - **Conformation a:** One methyl group in the axial position, others in equatorial. - **Conformation b:** Similar arrangement with axial and equatorial positioning. - **Conformation c:** Methyl groups in various axial positions, increasing steric hindrance. - **Conformation d:** Another varying arrangement of axial and equatorial methyl groups. - **Conformation e:** Methyl groups predominantly in equatorial positions, which generally minimizes steric clashes compared to axial positions. Thus, the selected answer E is considered to represent the most stable chair conformation of Molecule A, as it likely places the bulky methyl groups in positions that minimize steric strain.
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