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Muscle tissue takes a lot of nutrients and oxygen. Clearly, how hard the muscle is functioning affects how much of it is consumed. A total of 60% of the oxygen used during vigorous activity comes solely from the muscles. Additionally, muscle cells may operate anaerobically for a while without oxygen sources. As a result, phosphocreatine and muscle glycogen are found in significant quantities in muscle cells.The Cori cycle is at work when there is anaerobic metabolism; lactate from glycolysis is transported from the muscles to the liver where it is transformed into glucose through gluconeogenesis. The glucose is then returned to the muscle where it will be utilized as fuel. It should be noted that although part of the lactate that is turned into glucose may be stored as glycogen in the liver, this substance cannot be transferred from the liver to skeletal muscle. Hence, the blanks can be filled with lactate, liver, and glucose.