When is fibrin produced during the coagulation cascade? O intrinsic pathway O extrinsic pathway common pathway O both intrinsic and extrinsic pathways
The correct answer is Option 3 - Common pathway
Explanation
A blood clot is a combination of blood cells, platelets, and fibrin. To form a stable blood clot, the body requires an enzyme called thrombin. The active form of thrombin is derived from an inactive molecule called Prothrombin.
When there is a signal to the body that injury to the blood vessels has occurred, the inactive prothrombin is converted to active thrombin.
There are two ways by which prothrombin can be converted into thrombin
1. Intrinsic pathway - In this coagulation pathway, the initiation factors of prothrombin are contained within the body itself (hence the name-intrinsic). These factors are - factors XII, XI, IX and VIII.
2. Extrinsic pathway - In this coagulation pathway, the initiation factors of prothrombin are external. They arise from vascular tissue injuries. A host of host factors are released (collectively called as tissue thromboplastin)
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