When heated, the DNA double helix separates into two random-coil single strands. When cooled, the random coils re-form the double helix: double helix ⇌2 random coils.(a) What is the sign of ΔS for the forward process? Why?(b) Energy must be added to overcome ΔH bonds and dispersion forces between the strands. What is the sign of ΔG for the for-ward process when TΔS is smaller than ΔH?(c) Write an expression that shows T in terms of ΔH and ΔS when the reaction is at equilibrium. (This temperature is calledthe melting temperatureof the nucleic acid.)

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When heated, the DNA double helix separates into two random-coil single strands. When cooled, the random coils re-form the double helix: double helix ⇌2 random coils.(a) What is the sign of ΔS for the forward process? Why?(b) Energy must be added to overcome ΔH bonds and dispersion forces between the strands. What is the sign of ΔG for the for-ward process when TΔS is smaller than ΔH?(c) Write an expression that shows T in terms of ΔH and ΔS when the reaction is at equilibrium. (This temperature is calledthe melting temperatureof the nucleic acid.)

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