When a native protein in solution is heated to a high enough temperature, its polypeptide chain will unfold to become the denatured protein. The temperature at which a large portion of the protein unfolds is called the melting temperature. The melting temperature of a certain protein is found to be 47°C, and the enthalpy of denaturation is 3.80 × 102 kJ/mol. Assume that the denaturation is a two-state process; that is, native protein → denatured protein The single protein chain has 123 amino acids. Calculate the entropy of denaturation per amino acid.

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When a native protein in solution is heated to a high enough temperature, its polypeptide chain will unfold to become the denatured protein. The temperature at which a large portion of the protein unfolds is called the melting temperature. The melting temperature of a certain protein is found to be 47°C, and the enthalpy of denaturation is 3.80 × 102 kJ/mol. Assume that the denaturation is a two-state process; that is,

native protein → denatured protein
 
The single protein chain has 123 amino acids. Calculate the entropy of denaturation per amino acid.
 

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