When a Levy-Jennings graph for TSH was checked, the mean of results was found to have shifted by +1.5 SD over the four days since the last check. All other assays were found to be performing as expected. On investigation, it was discovered that the batch of reagent had been changed. A phone call to the manufacturer revealed that there were no other reports of problems

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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When a Levy-Jennings graph for TSH was checked,
the mean of results was found to have
shifted by +1.5 SD over the four days since the last
check. All other assays were found to be
performing as expected. On investigation, it was
discovered that the batch of reagent had been
changed. A phone call to the manufacturer revealed
that there were no other reports of problems
with this batch. A more detailed investigation
revealed that each batch of reagent has a specific
calibrator, which can only be used for that batch.
(a) What type of error does this represent?
(b) What is the most likely cause of the problem?
(c) How would you resolve the problem?
Transcribed Image Text:When a Levy-Jennings graph for TSH was checked, the mean of results was found to have shifted by +1.5 SD over the four days since the last check. All other assays were found to be performing as expected. On investigation, it was discovered that the batch of reagent had been changed. A phone call to the manufacturer revealed that there were no other reports of problems with this batch. A more detailed investigation revealed that each batch of reagent has a specific calibrator, which can only be used for that batch. (a) What type of error does this represent? (b) What is the most likely cause of the problem? (c) How would you resolve the problem?
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