what TOO much GABA may present as clinically? and what NOT ENOUGH GABA may present as clinically?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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what TOO much GABA may present as clinically? and what NOT ENOUGH GABA may present as clinically?

 
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Gamma Aminobutyric Acid also abbreviated as GABA is an amino acid which acts as a neurotransmitter in the central nervous system. It has an important role in calming the nervous activity by inhibiting nerve transmission in the brain. It is found abundantly in the nigrostriatal system and also occur throughout the grey matter but in low concentration.

There are mainly two classes of GABA  receptors, namely, GABAA receptor and GABAB receptor. GABA plays numerous roles in the CNS such as it helps in relieving anxiety and pain, regulating the release of sex hormones, stabilizing the blood pressure etc. 

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