What mechanism determines differentiation of fore limb VS hind limb?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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What mechanism determines differentiation of fore limb VS hind limb?
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Introduction: Limbs means legs and arms present in humans.Forelimbs that are present in the front side are arms in human body.Hind limbs that are present in back side are legs of the human body.

The limbs are formed due to expression of Hox genes, it is a subclass of homeotic genes and T- box transcription factors.

Tbx5 factor is responsible for forelimb development and Tbx4 factor is responsible for leg or hindlimb development.

Limb formation takes place by a series of reciprocal tissue that interacts among the mesenchyme of the lateral plate mesoderm and the covering ectodermally derived epithelial cells.

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