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What is the percentage yield and write the reaction for this experiment . product weight =4.55g

What is the percentage yield and write the reaction for this experiment . product weight =4.55g

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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What is the percentage yield and write the reaction for this experiment .

product weight =4.55g

EXPERIMENT 2: Synthesis of a potential enzyme inhibitor AIM To undertake the synthesis of an enzyme inhibitor as a potential anti-tumour agent in the treatment of hormone-dependent breast cancer. INTRODUCTION: The enzyme estrone sulfatase (ES) is responsible for the conversion of stored estrogens (sulfated) to the active (non-sulfated) estrogens (Figure 1). HO- -0 но- 6 Figure 1. The reaction catalysed by the enzyme estrone sulfatase ES Inhibitors of this enzyme have shown to be useful in the fight against hormone-dependent breast cancer. In this experiment, you will synthesise a potential inhibitor of this enzyme i.e.: HC-fa CH₁₂ HO 15 H₂C 0 CH₂ METHOD Methane sulfonyl chloride is extremely lachrymatory as well as being sensitive to moisture and corrosive! The WHOLE of this practical MUST be carried out using a fume hood - no part of it is to be carried out in the general laboratory. Do not use naked flames AND do not walk around the laboratory with open top flasks. Add 3g of 4-hydroxyacetophenone to 70ml anhydrous dichloromethane in a 250cm³ round bottom flask. Then add 5ml of triethylamine and stir the mixture for a 1 minute. Cool the mixture to 0°C in an ice bath and add 3ml of methane sulfonyl chloride whilst stirring the solution by hand using a glass rod. Add 2-4 anti-bumping granules. Using a heating mantle, reflux the reaction mixture for 45 minutes. After cooling to room temperature, carefully pour the reaction mixture into a beaker containing approximately 100cm³ of ice. After the ice has melted, wash the dichloromethane layer twice with water (50ml each time). Wash the dichloromethane twice with saturated sodium bicarbonate (NaHCO3) solution (50ml each time) and finally once with water (80ml). Dry the dichloromethane layer over anhydrous magnesium sulfate. After filtering off the solid magnesium sulfate, remove the dichloromethane using a rotary evaporator. You should avoid smelling the product as there may still be some residue of methane sulfonyl chloride present in the round bottom flask. Record the weight and therefore determine the percentage yield.
Transcribed Image Text:EXPERIMENT 2: Synthesis of a potential enzyme inhibitor AIM To undertake the synthesis of an enzyme inhibitor as a potential anti-tumour agent in the treatment of hormone-dependent breast cancer. INTRODUCTION: The enzyme estrone sulfatase (ES) is responsible for the conversion of stored estrogens (sulfated) to the active (non-sulfated) estrogens (Figure 1). HO- -0 но- 6 Figure 1. The reaction catalysed by the enzyme estrone sulfatase ES Inhibitors of this enzyme have shown to be useful in the fight against hormone-dependent breast cancer. In this experiment, you will synthesise a potential inhibitor of this enzyme i.e.: HC-fa CH₁₂ HO 15 H₂C 0 CH₂ METHOD Methane sulfonyl chloride is extremely lachrymatory as well as being sensitive to moisture and corrosive! The WHOLE of this practical MUST be carried out using a fume hood - no part of it is to be carried out in the general laboratory. Do not use naked flames AND do not walk around the laboratory with open top flasks. Add 3g of 4-hydroxyacetophenone to 70ml anhydrous dichloromethane in a 250cm³ round bottom flask. Then add 5ml of triethylamine and stir the mixture for a 1 minute. Cool the mixture to 0°C in an ice bath and add 3ml of methane sulfonyl chloride whilst stirring the solution by hand using a glass rod. Add 2-4 anti-bumping granules. Using a heating mantle, reflux the reaction mixture for 45 minutes. After cooling to room temperature, carefully pour the reaction mixture into a beaker containing approximately 100cm³ of ice. After the ice has melted, wash the dichloromethane layer twice with water (50ml each time). Wash the dichloromethane twice with saturated sodium bicarbonate (NaHCO3) solution (50ml each time) and finally once with water (80ml). Dry the dichloromethane layer over anhydrous magnesium sulfate. After filtering off the solid magnesium sulfate, remove the dichloromethane using a rotary evaporator. You should avoid smelling the product as there may still be some residue of methane sulfonyl chloride present in the round bottom flask. Record the weight and therefore determine the percentage yield.
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