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- How is it that we are not in a state of continuous infection from the microbes we encounter every day?Describe the different ways a disease can be transmitted? What impact do we have as human that can support the control of transmission? What tactics, skills and/or techniques will you implement going forward to help control the transmission of microbes in your daily life?Select all of the following that applies to the tradeoff between transmission and virulence that applies to many diseases. a) The tradeoff between transmission and virulence means that diseases always evolve to become more virulent. b) If greater virulence limits transmission, that disease will likely evolve to become less virulent than it could be. c) While making more copies of itself can increase the likelihood of transmission occurring, too much replication of the disease can make the host so sick it won't leave the house and spread the disease. d) A strain of a disease that replicates enough to be transmitted, but not so much that the host gets too sick to move, will be favored by natural selection over strains that either make the host too sick or do not replicate enough to be transmitted. e) If a disease can spread without making its host sick (e.g. when the host is asymptomatic), then the tradeoff between transmission and virulence…
- Some pathogens, such as HIV, can be transmitted both vertically and horizontally. How do you expect virulence of such pathogens to compare with that of pathogens that are transmitted 1) only horizontally or 2) only vertically? Explain.Below are a list of virulence factors/ strategies paired with an example of an organism that utilizes them. How do each of the following strategies contribute to the virulence of the pathogen? Strategy - Causes the host to produce more receptors (Organism - Rhinovirus) Strategy - Produces gas as a product of fermentation (Organism - Clostridium perfringens) Strategy - Produces a capsule (organism - Klebsiella pneumonia) Strategy - Ability to move between adjacent cells (organism - Cytomegalovirus) Strategy - Ability to use pilus as a motility structure (organism - Pseudomonas aerogenosa)Why is transmission of cytomegalovirus (CMV) through blood components not a significant risk to most recipients? Question 10 options: a) Most recipients are CMV-positive. b) Most recipients are CMV-negative. c) The CMV cannot tolerate cold storage temperatures. d) None of the above.
- Please discuss how pathogens are so easily spread around the world in 2021? Why is a society or planet like ours especially susceptible to the rapid dissemination of pathogens? What are the mechanisms that move the pathogens?Why is virulence expected to increase with vector or water-borne transmission, relative to direct transmission? Using the concept of a “cost of virulence”, explain how vertical transmission or transmission in a hospital is thought to affect the level of virulence favored by natural selection?Identifying an unknown bacterium is an essential step in the diagnosis and treatment process. Since not every antibiotic is effective against every type of bacteria, knowing what caused a particular infection allows us to make correct prescriptions so patients can recover more quickly. Knowing the cause of an infection also prevents antibiotic resistance as well, since incorrect prescriptions allow bacteria to be unnecessarily be exposed to antibiotics, increasing the chances of developing resistance.