What is the biochemical mechanism by which ingesting 2,4-dinitrophenol (DNP) results in rapid weight loss by increased rates of metabolic flux through the fatty acid degradation pathway? DNP uncouples electron transport from ATP synthesis and the body degrades stored fatty acids at a high rate to increase the energy charge. DNP uncouples electron transport from ATP synthesis and the body stores excess fatty acids at a high rate to increase the energy charge. DNP transports protons from the mitochondrial matrix to the intermembrane space, which increases rates of fatty acid degradation leading to weight loss. DNP increases the efficiency of oxidative phosphorylation, which leads to high rates of fatty acid degradation to decrease energy charge. DNP is an inhibitor of ATP synthase, which increases NADH oxidation by Complex I in the electron transport system, the result is fatty acid degradation.
What is the biochemical mechanism by which ingesting 2,4-dinitrophenol (DNP) results in rapid weight loss by increased rates of metabolic flux through the fatty acid degradation pathway? DNP uncouples electron transport from ATP synthesis and the body degrades stored fatty acids at a high rate to increase the energy charge. DNP uncouples electron transport from ATP synthesis and the body stores excess fatty acids at a high rate to increase the energy charge. DNP transports protons from the mitochondrial matrix to the intermembrane space, which increases rates of fatty acid degradation leading to weight loss. DNP increases the efficiency of oxidative phosphorylation, which leads to high rates of fatty acid degradation to decrease energy charge. DNP is an inhibitor of ATP synthase, which increases NADH oxidation by Complex I in the electron transport system, the result is fatty acid degradation.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:What is the biochemical mechanism by which ingesting 2,4-dinitrophenol
(DNP) results in rapid weight loss by increased rates of metabolic flux
through the fatty acid degradation pathway?
DNP uncouples electron transport from ATP synthesis and the body
degrades stored fatty acids at a high rate to increase the energy charge.
DNP uncouples electron transport from ATP synthesis and the body
stores excess fatty acids at a high rate to increase the energy charge.
DNP transports protons from the mitochondrial matrix to the
intermembrane space, which increases rates of fatty acid degradation
leading to weight loss.
DNP increases the efficiency of oxidative phosphorylation, which leads
to high rates of fatty acid degradation to decrease energy charge.
DNP is an inhibitor of ATP synthase, which increases NADH oxidation by
Complex I in the electron transport system, the result is fatty acid
degradation.
estion 28 (1
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