Q: What is spontaneous mutation and how does it occur during Stress-Induced Mutagenesis.
A: The mutation is the sudden genetical changes that occurs in the DNA sequence and ultimately can or…
Q: What is the name given to study of biochemical nature of genes and how genes express their encoded…
A: Genes are the sequence of nucleotide bases present in the DNA in a cell. There are many genes in the…
Q: Starting with a sample of RNA that contains the mRNA for theβ-globin gene, explain how you could…
A: DNA is the genetic material that carries genetic information in the form of coded nucleotide…
Q: What are frameshift mutations with an example
A: Gene mutations are rare and random changes in DNA sequence which result in alteration of polypeptide…
Q: how to generate specific mutations in anyE. coli gene by gene targeting.
A: Transgenic organisms or the genetically modified organism contain the gene(s) of different organism…
Q: What is one stumbling block in AAV gene therapy in some patients?
A: Biotechnology is technology that utilizes biological systems, living organisms or parts of this to…
Q: List three possible uses of site-directed mutagenesis
A: BASIC INFORMATION MUTATION It is sudden or discontinuous variation These changes occurs in the…
Q: What is a transposon? Write a brief description of Tn5
A: TRANSPOSONS: It is a repetitive DNA sequence found in many multicellular organisms' genome(mainly in…
Q: Construct a table, concept map, or picture to summarize how base analogues, DNA-modifying agents,…
A: Table of mutations induced by base analogue ,intercalary agents and DNA modifying agents --…
Q: How geneticists used synthetic mRNAs to limit the coding possibilities?
A: Prior to the technology existed for RNA synthesis of defined sequence such as given in the figure…
Q: What are the considerations for choice of a vector in gene therapy?
A: HIV consists of single-stranded RNA in the replication form that has been transcribed into…
Q: What are transgenic plants?Give some example.
A: The genetically modified organism’s also known as bioengineered foods. There are several steps in…
Q: What is a chimera and how is it different from a “true transgenic animal”?
A: A chimera is an single organism with DNA of two or three different types in it. For example during…
Q: How a transgenic organism is made ?
A: Organisms that have had their DNA manipulated to possess and express and extra gene are known as…
Q: In general, why is it important to regulate genes? Discuss examples of situations in which it would…
A: Genes are sets of nucleotides that codes for a particular protein. The genes have to be expressed…
Q: . In selecting target cells to receive a transferred gene in gene therapy in an adult person, what…
A: To cure some of the human diseases gene therapy can be given to the patient. Gene therapy is the…
Q: What is an operon? Explain an inducible operon.
A: In genetics, an operon is a functioning unit of DNA containing a cluster of genes under the control…
Q: What is double-knockout animals (DKOs) ?
A: Gene is the basic unit of heredity of an organism. In most animals, Deoxyribonucleic acid (DNA) is…
Q: What are some advantages and disadvantages of using mathematical models to study biological…
A: An operon is defined as a group of genes that has a common promoter and regulator and also…
Q: How can site-directed mutagenesis be useful to enzymologists?
A: Mutagenesis is the biological process of changing genetic information or DNA of an organism and that…
Q: Briefly explain how synthetic probes are created to screen a DNA library when the protein encoded by…
A: Synthetic probe is fragment of DNA. to screen a DNA library RNA of variable length approximately 100…
Q: What is the difference between somatic gene therapy and germ-line gene therapy?
A: Gene is a functional unit of heredity. A gene is a sequence of nucleotides in genome that codes for…
Q: The first person to receive gene therapy was a young girl with adenosine desminase(ADA) deficiency.…
A: Gene treatment endeavors to treat cancer or boost the body's capacity to combat illness by…
Q: Which kind of therapy was given in 1990 to a four year old girl with adenosine deaminase (ADA)…
A: Answer: Introduction: ADA deficiency i.e. Adenosine deaminase deficiency is also called as severe…
Q: Compare CRISPR-based endonucleases with restriction endonucleases.
A: Introduction CRISPR and restriction enzymes are two types of gene modifying methods.
Q: What is lac operon system?
A: Lac operon is one of the method by which a prokaryotic cell control gene expression. The lac operon…
Q: Discuss the use of transposons as mutagens in bacteria.
A: Transposon A transposable element is a mobile element, also known as the jumping gene. This element…
Q: Why do gene targeting and mutagenesis screening in mice have potential benefits for humans?
A: Mice and humans have undoubtedly had the longest relationship among mammals and mouse had a…
Q: Treatment of adenosine deaminase (ADA) deficiency is an exampleof ex vivo gene therapy. Why is this…
A: Gene therapy is a collection of methods that allows correction of a gene defect that has been…
Q: What is Central Dogma of Molecular Biology and how this concept is used in the development of…
A: Genetically modified organisms are those that have been modified by humans in order to show those…
Q: What is the purpose of RNA editing?
A: RNA (ribonucleic acid) is an intermediate molecule that is synthesized from DNA (deoxyribonucleic…
Q: Why is it necessary to examine gene-expression profiles, in additionto genome sequences, for…
A: Gene expression profiling is the analysis of the behaviour of thousands of genes at once to…
Q: Give any two examples of products, how transgenic animals can be used to produce biological…
A: Transgenic animals are the animals that have been produced by the use of biotechnology. It is the…
Q: What are the differences between somatic and germline gene editing? Is there any scientific example…
A: Gene therapy is a widely used technique to treat genetic disorders. There are two types of gene…
Q: What is Gene therapy – Illustrate using example of Adenosine deaminase deficiency?
A: Genetic engineering is a process through which the desired gene of interest is introduced into the…
Q: What is miRNA replacement therapy? Describe three examples of this treatment approach.
A: A Gene is a unit of heredity containing the fundamental information of life as a distinct sequence…
Q: What is RNA Silencing? How is this strategy used to create pest – resistant plants?
A: The process of regulation of gene expression to prevent the expression of a particular gene is…
Q: Transposable elements alter the genome by making what changes to genes?
A: Transposition may be related to replication, recombination, and repair. Insertion of transposable…
Q: What are conditional knockout mice?
A: A knockout mouse (conventional knockout) is a genetically modified mouse in which the researchers…
Q: Please give one observation of the genetic code that indicates it minimizes the harmful effects of…
A: Changes in the genetic sequence of a gene that can alter the expression of a genotype are called…
Q: Explain how site-directed mutagenesis can be used to produce an altered protein in bacterial cells.
A: Site-directed mutagenesis is a molecular biology technique that is used to make specific and…
Q: What is the purpose of transgenesis?
A: Genetic engineering is the process of using recombinant DNA (rDNA) technology to alter the genetic…
Q: How could site-directed mutagenesis be used to investigate the kinetic properties of an enzyme?
A: Site-directed mutagenesis is a molecular biology method that is used to make specific and…
Q: What is gene targeting? Give some examples of gene targeting?
A: Gene is a stretch of DNA in a chromosome which codes for a functional product either in the form of…
Q: What is operon? How does the lac operon work?
A: A specific sequence of nucleotides in DNA is called DNA. It is a hereditary unit which is…
Q: What is lac operon? Draw and/or identify the status of the lac operon in a given set of…
A: The lac operon, otherwise called as lactose operon is an example of inducible operon. It consists of…
Q: single gene mutation
A: Introduction : Variations (or mutations) in the DNA sequence of a particular gene are what's…
What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency.
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- What is Gene therapy – Illustrate using example of Adenosine deaminase deficiency?Which mechanisms for regulating gene expression may be applied for the treatment of such diseases? Propose a method of treatment. Explain how it might work. Reference: https://link.springer.com/article/10.1186/ar3317Name three different types of loss of function mutations and in each case explain how the mutation exerts a loss of function effect on a gene
- Discuss briefly the effects of colchicine treatment on cells. What are the genetic implications of such effects?Discuss how the cloning and expression of certain genes allows for massive production of the desired product. For Example: the cloning and expression of insulin in bacteria allows for the mass production of this necessary protein for use by diabetic patients.Define the use of carotene desaturase (crtI) gene ?
- A number of mutations affect the expression of the lac operon in E. coli. The genotypes of several E. coli strains are shown below. ("+" indicates a wild-type gene with normal function and "-" indicates a loss-of-function allele.) Please predict which of the following strains would have the lowest beta-galactosidase enzyme activity, when grown in the lactose medium. Orpt o* z* r* Orpt ot z* Y OrptoztY Orrotzr OrPotz*YAlthough it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?Could someone please give me a technical description of how the chemotaxis systems work in gene regulation? Thank you
- Why is the ErbB family pathway an important pathway for researchers that target cancer therapy. explain in 3-5 sentences.RNAi is currently being tested as a therapeutic tool for genetic diseases and other conditions. Consider the following: cystic fibrosis caused by loss of function of the CFTR gene, HIV infection, and cancer caused by hyperactivity of a growth factor receptor. Which of these may be treatable by RNAi, and which not? Explain your reasoning.Several research studies are under way that involve the use of genetherapies to inhibit the growth of cancer cells. Oncogenes are mutant genes that are overexpressed and cause cancer. New gene therapies are aimed at silencing oncogenes by producing antisense RNA that recognizes the mRNAtranscribed from oncogenes. Based on your understanding of antisense RNA , explain how this strategy would prevent the growth of cancer cells.