Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
What is a homeodomain protein?
Homeodomain proteins belong to the large family of transcription factors. They have conserved 60 amino acid sequences and are also known as master regulatory proteins since a single protein can control the expression of many genes. They regulate the gene expression of protein involved in the formation of body axes and structure during early embryonic development. First discovery in drosophila, the genes encoding these proteins are known as HOX genes.
Homeodomain consist of three alpha helix motif formed from 60 conserved amino acid sequences. Helix 2 and 3 are responsible for forming helix turn helix structure which is connect by a shoot loop. Third helix directly interacts with the major grooves of DNA via hydrogen or hydrophobic interactions.
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