What happened to the hydrogen labeled in green? Part [2] Addition of the nucleophile and loss of the leaving group H. :0: H :ö: :0: .R' R ö N: 'N: nucleophilic attack loss of the H-N H R R' leaving group H R'NH2 amide 3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate. 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide.

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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What happened to the hydrogen labeled in green?
Part [2] Addition of the nucleophile and loss of the leaving group
H.
:0:
H
:ö:
:0:
.R'
R ö
N:
'N:
nucleophilic
attack
loss of the
H-N
H
R
R'
leaving group
H
R'NH2
amide
3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate.
5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide.
Transcribed Image Text:What happened to the hydrogen labeled in green? Part [2] Addition of the nucleophile and loss of the leaving group H. :0: H :ö: :0: .R' R ö N: 'N: nucleophilic attack loss of the H-N H R R' leaving group H R'NH2 amide 3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate. 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide.
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