Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
What are the reagents for the following reactions?
![OH
i-t
2.
O
-0
ii
Choices:
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5.
OH
AAA. HCI
BBB. CH3CH₂CH₂MgBr then H+
CCC. Cul₂
DDD. Fehling's Reagent
EEE. MeOH
FFF. Heat, HCI
OH
N
N-H
Avio-
OH
CIO
7.
8.
N=N:
OH
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OH
GGG. Zn(Hg), concentrated HCI
HHH. KI
III. acidic KMnO4, heat
JJJ. SOCI₂
KKK. LIAIH4, dry EtOH then H+
LLL. MeOH, H+
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