7 (10)What are the advantages of using a multidimensional HPLC separation for the analysis ofcomplex samples?Discuss some of the problems that might be encountered in a two dimensional(11)separation using HPLC.Discuss the advantages and limitations of space-space based two dimensionalseparations, in comparison to time-time based two dimensional separations.Explain the difference between comprehensive two-dimensional HPLC and heart-cuttingtwo dimensional HPLC. Explain when either technique might be an advantage over the(12)(13)other.(14)What is the 'wrap around' effect in two dimensional HPLC and how can this be avoided?

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What are the advantages of using a multidimensional HPLC separation for the analysis of complex samples?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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Question

(10)
What are the advantages of using a multidimensional HPLC separation for the analysis of
complex samples?
Discuss some of the problems that might be encountered in a two dimensional
(11)
separation using HPLC.
Discuss the advantages and limitations of space-space based two dimensional
separations, in comparison to time-time based two dimensional separations.
Explain the difference between comprehensive two-dimensional HPLC and heart-cutting
two dimensional HPLC. Explain when either technique might be an advantage over the
(12)
(13)
other.
(14)
What is the 'wrap around' effect in two dimensional HPLC and how can this be avoided?

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