What are the advantages of using a multidimensional HPLC separation for the analysis of complex samples?

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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(10)
What are the advantages of using a multidimensional HPLC separation for the analysis of
complex samples?
Discuss some of the problems that might be encountered in a two dimensional
(11)
separation using HPLC.
Discuss the advantages and limitations of space-space based two dimensional
separations, in comparison to time-time based two dimensional separations.
Explain the difference between comprehensive two-dimensional HPLC and heart-cutting
two dimensional HPLC. Explain when either technique might be an advantage over the
(12)
(13)
other.
(14)
What is the 'wrap around' effect in two dimensional HPLC and how can this be avoided?
Transcribed Image Text:(10) What are the advantages of using a multidimensional HPLC separation for the analysis of complex samples? Discuss some of the problems that might be encountered in a two dimensional (11) separation using HPLC. Discuss the advantages and limitations of space-space based two dimensional separations, in comparison to time-time based two dimensional separations. Explain the difference between comprehensive two-dimensional HPLC and heart-cutting two dimensional HPLC. Explain when either technique might be an advantage over the (12) (13) other. (14) What is the 'wrap around' effect in two dimensional HPLC and how can this be avoided?
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