What are the absolute configurations of these two molecules? CH,Br H+OCH, ČH,CH, SH H,CH2C Co,H H3C (S) and I(S) KS) and I(R) MR) and II(5) MR) and II(R) A. В. C. D. OD

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### Determining the Absolute Configurations of Chiral Molecules

**Question: What are the absolute configurations of these two molecules?**

The two molecules are represented as follows:

**Molecule I:**
```
     SH
     |
H3CH2C---CO2H
  |
 H3C
```
**Molecule II:**
```
    CH2Br
       |
       H---OCH3
      |
   CH2CH3
```

**Possible Absolute Configurations:**
- **A.** I(S) and II(S)
- **B.** I(S) and II(R)
- **C.** I(R) and II(S)
- **D.** I(R) and II(R)

**Options for Answer:**
- O D
- O A
- O C
- O B

To determine the absolute configuration (R or S), one must apply the Cahn-Ingold-Prelog priority rules to each chiral center in the molecules. The molecules are depicted above for clarification.

Let's review each molecule step by step to infer the configurations:

1. Assign priority to the groups attached to the chiral carbon.
2. Orient the molecule so that the group of the lowest priority is oriented away from you.
3. Determine the order of the groups from highest priority (1) to lowest priority (3) around the chiral center.

After completing these steps for both molecules, and based on the given configurations, choose the appropriate answer among the given options.

**Discussion:**
Understanding and determining the absolute configuration is fundamental in organic chemistry, especially when distinguishing between enantiomers. This skill is crucial for predicting the behavior of molecules in biochemical systems, including drug molecules.

**Answer Key:**
*Instructors may provide further resources or an answer key separately for students to verify their understanding.*
Transcribed Image Text:### Determining the Absolute Configurations of Chiral Molecules **Question: What are the absolute configurations of these two molecules?** The two molecules are represented as follows: **Molecule I:** ``` SH | H3CH2C---CO2H | H3C ``` **Molecule II:** ``` CH2Br | H---OCH3 | CH2CH3 ``` **Possible Absolute Configurations:** - **A.** I(S) and II(S) - **B.** I(S) and II(R) - **C.** I(R) and II(S) - **D.** I(R) and II(R) **Options for Answer:** - O D - O A - O C - O B To determine the absolute configuration (R or S), one must apply the Cahn-Ingold-Prelog priority rules to each chiral center in the molecules. The molecules are depicted above for clarification. Let's review each molecule step by step to infer the configurations: 1. Assign priority to the groups attached to the chiral carbon. 2. Orient the molecule so that the group of the lowest priority is oriented away from you. 3. Determine the order of the groups from highest priority (1) to lowest priority (3) around the chiral center. After completing these steps for both molecules, and based on the given configurations, choose the appropriate answer among the given options. **Discussion:** Understanding and determining the absolute configuration is fundamental in organic chemistry, especially when distinguishing between enantiomers. This skill is crucial for predicting the behavior of molecules in biochemical systems, including drug molecules. **Answer Key:** *Instructors may provide further resources or an answer key separately for students to verify their understanding.*
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