Electronic Effects
The effect of electrons that are located in the chemical bonds within the atoms of the molecule is termed an electronic effect. The electronic effect is also explained as the effect through which the reactivity of the compound in one portion is controlled by the electron repulsion or attraction producing in another portion of the molecule.
Drawing Resonance Forms
In organic chemistry, resonance may be a mental exercise that illustrates the delocalization of electrons inside molecules within the valence bond theory of octet bonding. It entails creating several Lewis structures that, when combined, reflect the molecule's entire electronic structure. One Lewis diagram cannot explain the bonding (lone pair, double bond, octet) elaborately. A hybrid describes a combination of possible resonance structures that represents the entire delocalization of electrons within the molecule.
Using Molecular Structure To Predict Equilibrium
Equilibrium does not always imply an equal presence of reactants and products. This signifies that the reaction reaches a point when reactant and product quantities remain constant as the rate of forward and backward reaction is the same. Molecular structures of various compounds can help in predicting equilibrium.
What are all the resonance structures for pregabalin
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ne following problem concerns the molecule pregabalin, which is sold under the brand name Lyrica.
is drug was introduced by Pfizer in 2005 for neuropathic pain and fibromyalgia. The molecule grossed
1.2 Billion in sales during its first year on the market. Pregabalin was developed and patented by Prof.
Richard Silverman and Northwestern University. The patent was licensed to Pfizer for ~$360 million, of
which Prof. Silverman and his co-inventors received 40%. [FYI: Organic Chemistry can be profitable].
[concepts: nomenclature, structure]
pregabalin (Lyrica)
OUT
44
Part I. Circle all the sp² hybridized carbons in Lyrica
Part II. Circle the iso-propyl group in Lyrica
Part III. How many resonance structures does Lyrica have (including the
main contributor already drawn)?
Part IV. Place a box around all of the methylene groups in Lyrica
6. The following problem is designed to test your mastery of nomenclature.
Part I. Provide an IUPAC name for the following hydrocarbon
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