We intend to design a system for optimal control (u₁(t), u2(t)) which represent the Tuberculosis (TB) treatment rates for latent class and infectious class, respectively. Our target is to minimize the TB infected individuals (including latent and infectious individuals) as well as the costs required to con- trol TB by treating latent and infectious individuals, over a certain time horizon [0,tf]. The cost of each intervention is assumed to be proportional to the square of its intensity. Thus we formulate the optimization problem below. Minimize the objective function ' A₁E(t) + A₂I(t) + ¹¹³u²(t) + Bu²(t) J(u(.)), u(·) = "h 1 subject to dS = A(1p) BSI+ kV - ds, dt dV dt dE ུ|ཙ⪜ཊྛི|༴ཁྱི|ཙ dt dt = Ap-kV - dV, = BSI - (u(t) ++ d)E + OR, dR = E-(d--u2(t))I, = u₁(t)Eu(t) (d+ 0)R S(0) = So≥0, V(0) = √≥0, E(0) = Eo ≥0,1(0) = 10 ≥0, R(0) = Ro≥ 0. The control variables are assumed to be bounded: Given any t > 0, 0
We intend to design a system for optimal control (u₁(t), u2(t)) which represent the Tuberculosis (TB) treatment rates for latent class and infectious class, respectively. Our target is to minimize the TB infected individuals (including latent and infectious individuals) as well as the costs required to con- trol TB by treating latent and infectious individuals, over a certain time horizon [0,tf]. The cost of each intervention is assumed to be proportional to the square of its intensity. Thus we formulate the optimization problem below. Minimize the objective function ' A₁E(t) + A₂I(t) + ¹¹³u²(t) + Bu²(t) J(u(.)), u(·) = "h 1 subject to dS = A(1p) BSI+ kV - ds, dt dV dt dE ུ|ཙ⪜ཊྛི|༴ཁྱི|ཙ dt dt = Ap-kV - dV, = BSI - (u(t) ++ d)E + OR, dR = E-(d--u2(t))I, = u₁(t)Eu(t) (d+ 0)R S(0) = So≥0, V(0) = √≥0, E(0) = Eo ≥0,1(0) = 10 ≥0, R(0) = Ro≥ 0. The control variables are assumed to be bounded: Given any t > 0, 0
Advanced Engineering Mathematics
10th Edition
ISBN:9780470458365
Author:Erwin Kreyszig
Publisher:Erwin Kreyszig
Chapter2: Second-order Linear Odes
Section: Chapter Questions
Problem 1RQ
Related questions
Question
KINDLY PROVIDE FULL DETAILS AND CALCUTLATIONS WITH ANSWERS AND NOT JUST HOW TO DO IT
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps with 15 images
Similar questions
Recommended textbooks for you
Advanced Engineering Mathematics
Advanced Math
ISBN:
9780470458365
Author:
Erwin Kreyszig
Publisher:
Wiley, John & Sons, Incorporated
Numerical Methods for Engineers
Advanced Math
ISBN:
9780073397924
Author:
Steven C. Chapra Dr., Raymond P. Canale
Publisher:
McGraw-Hill Education
Introductory Mathematics for Engineering Applicat…
Advanced Math
ISBN:
9781118141809
Author:
Nathan Klingbeil
Publisher:
WILEY
Advanced Engineering Mathematics
Advanced Math
ISBN:
9780470458365
Author:
Erwin Kreyszig
Publisher:
Wiley, John & Sons, Incorporated
Numerical Methods for Engineers
Advanced Math
ISBN:
9780073397924
Author:
Steven C. Chapra Dr., Raymond P. Canale
Publisher:
McGraw-Hill Education
Introductory Mathematics for Engineering Applicat…
Advanced Math
ISBN:
9781118141809
Author:
Nathan Klingbeil
Publisher:
WILEY
Mathematics For Machine Technology
Advanced Math
ISBN:
9781337798310
Author:
Peterson, John.
Publisher:
Cengage Learning,