Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. That time he had a temperature of 10F and a runny nose. The emergency physician checked Bailey over but sent him home saying it was only a com- mon cold, probably brought home by his older sib- lings, and that all would be fine. But Bailey's health has not been fine as he has been having an unusual number of bacterial infections and he is not yet quite 1 year old. The antibiotics that Bailey's physician prescribed have cleared up his bacterial respiratory infections but another infection always follows. Now that Bailey is back at the hospital with pneu- monia, his physician has ordered a number of other laboratory tests as he is now worried about Bailey's immune system. The studies showed that Bailey had normal levels of B cells and T cells, with his immu- noglobulin levels and hematology results listed in CASE STUDY TABLE 11-1.1. CASE STUDY TABLE 11-1.1 LABORATORY RESULTS BAILEY'S VALUE TEST REFERENCE RANGE 6 mo-2 y: 30.9-37.0% 6 mo-2 y: 10.3-12.4 g/dL Hct 35% Hgb 11.9 g/dL 14.0 x 10/uL 6 mo-2 y: 6.2-14.5 x 10/uL 153 mg/dL 576 mg/dL 11 mg/dL O mg/dl 1 kIU/L 8.7 g/dl WBC IgG 1-3 y: 507-1,407 mg/dL. 1-3 y: 18-171 mg/dL IgM IgA IgD IgE 1-3 y: 63-298 mg/dL Newborn to adult: 0-8 mg/dL 1-3 y: <90 kIU/L Total 1 y: 5.4-7.5 g/dL protein Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. List the immunoglobulin types, Bailey's level as nor- mal or abnormal, and the function(s) of each type. 2. Why do Bailey's recurring bacterial infections cor- relate with these laboratory results? 3. What is immunoglobulin isotype switching? How does isotype switching explain the lack of IgG, IgA, and IgE in Bailey's blood? 4. List the immunoglobulin type and the age it appears in the blood of a baby from birth to 18 months. 5. What treatment can be given to Bailey? Immediately? In the future?
Victoria and Rusty were worried about their infant Bailey since his first trip to the hospital at 3 weeks of age. That time he had a temperature of 10F and a runny nose. The emergency physician checked Bailey over but sent him home saying it was only a com- mon cold, probably brought home by his older sib- lings, and that all would be fine. But Bailey's health has not been fine as he has been having an unusual number of bacterial infections and he is not yet quite 1 year old. The antibiotics that Bailey's physician prescribed have cleared up his bacterial respiratory infections but another infection always follows. Now that Bailey is back at the hospital with pneu- monia, his physician has ordered a number of other laboratory tests as he is now worried about Bailey's immune system. The studies showed that Bailey had normal levels of B cells and T cells, with his immu- noglobulin levels and hematology results listed in CASE STUDY TABLE 11-1.1. CASE STUDY TABLE 11-1.1 LABORATORY RESULTS BAILEY'S VALUE TEST REFERENCE RANGE 6 mo-2 y: 30.9-37.0% 6 mo-2 y: 10.3-12.4 g/dL Hct 35% Hgb 11.9 g/dL 14.0 x 10/uL 6 mo-2 y: 6.2-14.5 x 10/uL 153 mg/dL 576 mg/dL 11 mg/dL O mg/dl 1 kIU/L 8.7 g/dl WBC IgG 1-3 y: 507-1,407 mg/dL. 1-3 y: 18-171 mg/dL IgM IgA IgD IgE 1-3 y: 63-298 mg/dL Newborn to adult: 0-8 mg/dL 1-3 y: <90 kIU/L Total 1 y: 5.4-7.5 g/dL protein Albumin 3.8 g/dL 1-3 y: 3.4-4.2 g/dL Questions 1. List the immunoglobulin types, Bailey's level as nor- mal or abnormal, and the function(s) of each type. 2. Why do Bailey's recurring bacterial infections cor- relate with these laboratory results? 3. What is immunoglobulin isotype switching? How does isotype switching explain the lack of IgG, IgA, and IgE in Bailey's blood? 4. List the immunoglobulin type and the age it appears in the blood of a baby from birth to 18 months. 5. What treatment can be given to Bailey? Immediately? In the future?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Question
Answer all questions. Thank you.
Transcribed Image Text:Victoria and Rusty were worried about their infant
Bailey since his first trip to the hospital at 3 weeks of
age. That time he had a temperature of 103'F and a
runny nose. The emergency physician checked Bailey
over but sent him home saying it was only a com-
mon cold, probably brought home by his older sib-
lings, and that all would be fine. But Bailey's health
has not been fine as he has been having an unusual
number of bacterial infections and he is not yet quite
1 year old. The antibiotics that Bailey's physician
prescribed have cleared up his bacterial respiratory
infections but another infection always follows.
Now that Bailey is back at the hospital with pneu-
monia, his physician has ordered a number of other
laboratory tests as he is now worried about Bailey's
immune system. The studies showed that Bailey had
normal levels of B cells and T cells, with his immu-
noglobulin levels and hematology results listed in
CASE STUDY TABLE 11-1.1.
CASE STUDY TABLE 11-1.1
LABORATORY RESULTS
BAILEY'S
TEST
VALUE
REFERENCE RANGE
6 mo-2 y: 30.9-37.0%
6 mo-2 y: 10.3-12.4 g/dL
14.0 x 10/uL 6 mo-2 y: 6.2-14.5 x 10/uL
Hct
35%
Hgb
11.9 g/dL
WBC
IgG
153 mg/dL
1-3 y: 507-1,407 mg/dL
576 mg/dL
11 mg/dL
O mg/dL
IgM
1-3 y: 18-171 mg/dL
IgA
1-3 y: 63-298 mg/dL
IgD
Newborn to adult: 0-8 mg/dL
IgE
1 kIU/L
1-3 y: <90 klU/L
8.7 g/dl
Total
protein
Albumin 3.8 g/dL
1 y: 5.4-7.5 g/dL
1-3 y: 3.4-4.2 g/dL
Questions
1. List the immunoglobulin types, Bailey's level as nor-
mal or abnormal, and the function(s) of each type.
2. Why do Bailey's recurring bacterial infections cor-
relate with these laboratory results?
3. What is immunoglobulin isotype switching? How
does isotype switching explain the lack of IgG,
IgA, and IgE in Bailey's blood?
4. List the immunoglobulin type and the age it appears
in the blood of a baby from birth to 18 months.
5. What treatment can be given to Bailey?
Immediately? In the future?
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education