V Figure 12.16 Molecular control of the cell cycle at the G, checkpoint. The steps of the cell gdle are timed by rhythmic fluctuations in the activity of cyclin-dependent kinases (Cdis). Here we focus on a cyclin-Cdk complex in animal cells called MPF, which acts at the G, checkpoint as a go-ahead signal, triggering the events of mitosis. M GIS G M G2 M MPF activity Cyclin concentration Time (a) Fluctuation of MPF activity and cydlın concentration during the cell cycle O ynthesis of cyclin begins In late s phase and continues through G2. Because cyclin Is protected from degra- dation during this stage, It accumulates. O During G1. the degradation of cyclin continues, and the Cdk component of MPF Is recycled. cdk Degraded cydin G2 cdk checkpoint Cyclin i degraded Cyclin MPF ODuring anaphase, the cydlin com- ponent of MPF Is degraded, terminating the M phase. The cell enters the Gi phase. O MPF promotes mitosis by phos- phorylating varlous protelns. MPF's activity peaks during metaphase. Ogyclin combines with Cdk, producing MPF. When enough MPF molecules accumulate, the cell passes the G2 checkpolnt and begins mitosis. (b) Molecular mechantsms that help regulate the cell cycle cydin accumulation
V Figure 12.16 Molecular control of the cell cycle at the G, checkpoint. The steps of the cell gdle are timed by rhythmic fluctuations in the activity of cyclin-dependent kinases (Cdis). Here we focus on a cyclin-Cdk complex in animal cells called MPF, which acts at the G, checkpoint as a go-ahead signal, triggering the events of mitosis. M GIS G M G2 M MPF activity Cyclin concentration Time (a) Fluctuation of MPF activity and cydlın concentration during the cell cycle O ynthesis of cyclin begins In late s phase and continues through G2. Because cyclin Is protected from degra- dation during this stage, It accumulates. O During G1. the degradation of cyclin continues, and the Cdk component of MPF Is recycled. cdk Degraded cydin G2 cdk checkpoint Cyclin i degraded Cyclin MPF ODuring anaphase, the cydlin com- ponent of MPF Is degraded, terminating the M phase. The cell enters the Gi phase. O MPF promotes mitosis by phos- phorylating varlous protelns. MPF's activity peaks during metaphase. Ogyclin combines with Cdk, producing MPF. When enough MPF molecules accumulate, the cell passes the G2 checkpolnt and begins mitosis. (b) Molecular mechantsms that help regulate the cell cycle cydin accumulation
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
Problem 19P: Figure 28.11 depicts the eukaryotic cell cycle. Many cell types “exit� the cell cycle and...
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Review Figure 12.16 on cell cycle control. Would you expect MPF (maturation-promoting factor) activity to remain steady during cleavage? Explain.
Transcribed Image Text:V Figure 12.16 Molecular control of the cell cycle at the
G, checkpoint. The steps of the cell gdle are timed by rhythmic
fluctuations in the activity of cyclin-dependent kinases (Cdis). Here we
focus on a cyclin-Cdk complex in animal cells called MPF, which acts at
the G, checkpoint as a go-ahead signal, triggering the events of mitosis.
M
GIS G
M
G2
M
MPF activity
Cyclin
concentration
Time
(a) Fluctuation of MPF activity and cydlın concentration during
the cell cycle
O ynthesis of cyclin
begins In late s phase
and continues through
G2. Because cyclin Is
protected from degra-
dation during this stage,
It accumulates.
O During G1. the degradation
of cyclin continues, and
the Cdk component of
MPF Is recycled.
cdk
Degraded
cydin
G2
cdk
checkpoint
Cyclin i
degraded
Cyclin
MPF
ODuring
anaphase, the
cydlin com-
ponent of MPF Is
degraded,
terminating the
M phase. The
cell enters the
Gi phase.
O MPF promotes
mitosis by phos-
phorylating
varlous protelns.
MPF's activity
peaks during
metaphase.
Ogyclin combines
with Cdk, producing
MPF. When enough
MPF molecules
accumulate, the cell
passes the G2
checkpolnt and
begins mitosis.
(b) Molecular mechantsms that help regulate the cell cycle
cydin accumulation
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