Using this info, please calculate two theoretical yields for (1) p-acetamidobenzenesulfonamide and (2) sulfathiazole. Amounts used in experiment: 2-Amino thiazole = 0.3 g 4-acetamidobenzenesulfonyl chloride = 0.75 g Dry Acetonitrile = 1.5 mL Dry K2CO3 = 2 equiv. HCl = 10 mL
Using this info, please calculate two theoretical yields for (1) p-acetamidobenzenesulfonamide and (2) sulfathiazole. Amounts used in experiment: 2-Amino thiazole = 0.3 g 4-acetamidobenzenesulfonyl chloride = 0.75 g Dry Acetonitrile = 1.5 mL Dry K2CO3 = 2 equiv. HCl = 10 mL
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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Using this info, please calculate two theoretical yields for (1) p-acetamidobenzenesulfonamide and (2) sulfathiazole.
Amounts used in experiment:
2-Amino thiazole = 0.3 g
4-acetamidobenzenesulfonyl chloride = 0.75 g
Dry Acetonitrile = 1.5 mL
Dry K2CO3 = 2 equiv.
HCl = 10 mL

Transcribed Image Text:Scheme 2. Synthesis of Sulfathiazole
dry CH3CN,
K2CO3
HCI
CI-
NHCOCH3
+
-NHCOCH3
-NH2
NH2 reflux, 25 min
reflux, 30 min
4-acetamidobenzenesulfonyl chloride
2-aminothiazole
p-acetamidobenzenesulfonamide
sulfathiazole
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