Using this info, please calculate two theoretical yields for (1) p-acetamidobenzenesulfonamide and (2) sulfathiazole.  Amounts used in experiment: 2-Amino thiazole = 0.3 g 4-acetamidobenzenesulfonyl chloride = 0.75 g Dry Acetonitrile = 1.5 mL Dry K2CO3 = 2 equiv. HCl = 10 mL

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Using this info, please calculate two theoretical yields for (1) p-acetamidobenzenesulfonamide and (2) sulfathiazole. 

Amounts used in experiment:

2-Amino thiazole = 0.3 g

4-acetamidobenzenesulfonyl chloride = 0.75 g

Dry Acetonitrile = 1.5 mL

Dry K2CO3 = 2 equiv.

HCl = 10 mL

 

Scheme 2. Synthesis of Sulfathiazole
dry CH3CN,
K2CO3
HCI
CI-
NHCOCH3
+
-NHCOCH3
-NH2
NH2 reflux, 25 min
reflux, 30 min
4-acetamidobenzenesulfonyl chloride
2-aminothiazole
p-acetamidobenzenesulfonamide
sulfathiazole
Transcribed Image Text:Scheme 2. Synthesis of Sulfathiazole dry CH3CN, K2CO3 HCI CI- NHCOCH3 + -NHCOCH3 -NH2 NH2 reflux, 25 min reflux, 30 min 4-acetamidobenzenesulfonyl chloride 2-aminothiazole p-acetamidobenzenesulfonamide sulfathiazole
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