Use the CIP rules to prioritize the following four groups from highest to lowest priority. Your answer should be written as: A-B-C-D or A, B, C, D with explanation. {-OH Answer: Check A B C D

Predict the major products of the follow ing. (c) (a) (b) CI HO,S HNO3 Cl2, ? AICI3 FeCla H,SO, H3CO (e) (d) Br2, ? Conc. HNO, ? FeBr3

The pk, of phenol (C,H5OH) is 10.0. When a methyl (CH3) group is attached to the ring, the pK, increases, as shown here for the ortho, meta, and para isomers. OH ОН ОН ОН CH3 (a) Explain why the pk, values of all three isomers are higher than the pk, of phenol itself. (b) Explain why the meta isomer has the lowest pk, of CH3 Phenol CH3 the three isomers. pKa = 10.0 10.3 10.1 10.2

Imagine the following substituents connected to a benzene ring. Decide which ofthem are electron donating and which are electron withdrawing.

What are the products (major) and their configuration

Do for all elements

Consider the following reaction scheme,

- consider both regio Selectivity and Stereoslectivita to Predict the praducts for the Se elimmations, KOIBU NaOme

and breaking for each of the following events. (b) Draw approximate transition state (TS), including partial electron-densities, for each. b. COH2 H3C H,C-ce :Br: H3C + H20 H3C H3C-C Br: H3C TS = TS = CH3 H3C Br d. C. :Br: HCI :CI: TS = TS =

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