uence below shows a part of the genetic code for the HBB Gene. This gene provides the instructions for making a protein called beta-globin. The gene sequence is shown below. Use the sequence to create RNA and the sequence of amino acids. DNA of HbA - hemoglobin in normal adults DNA 3'to 5' RNA Amino Acid DNA a chain DNA of HbS- hemoglobin found in individuals with sickle cell anemia RNA CAC GTG GAC TGA GGA био каскиваси сси Amino Acid Hemoglobin Each amino acid in the chain joins together and then folds into a three dimensional shape - a PROTEIN. In most people, that protein is fully functional and results in blood cells that have a round shape and can bind with oxygen efficiently. What would happen if one small change occurs? Tron Fo CTT CTC GAA GAG CAC GTG GAC TGA GGA CAT CTC

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Case Study: DNA, Proteins, and Sickle Cell
Sickle cell is a disease where a person has abnormally shaped blood cells.
The reason for the abnormal shape of blood lies in the underlying genetic
code.
The sequence below shows a part of the genetic code for the HBB Gene.
This gene provides the instructions for making a protein called beta-globin.
The gene sequence is shown below. Use the sequence to create RNA and
the sequence of amino acids.
DNA of HbA - hemoglobin in normal adults
DNA
3'to 5'
RNA
Amino Acid
Name lexic Galbirat
DNA
CAC GTG GAC TGA
биокас
RNA
Amino Acid
Polypeptide
chain
B chain.
Ⓡ9
GGA
сивасикси
DNA of HbS- hemoglobin found in individuals with sickle cell anemia
Each amino acid in the chain joins together and then folds into a three dimensional shape - a PROTEIN. In
most people, that protein is fully functional and results in blood cells that have a round shape and can bind
with oxygen efficiently. What would happen if one small change occurs?
Hemoglobin
CTT CTC
GAA GAG
CAC GTG GAC TGA GGA CAT
Developed by: https://www.biologycorner.com/
CTC
The change in the sequence of HbS causes the blood cells to be shaped like sausages, rather than round.
These cells cannot bind oxygen as efficiently and become clogged in tiny capillaries. The result is a person who
is ANEMIC, or has low amounts of oxygen in their blood, which will make a person feel tired. The abnormal
cells can become clumped together causing blood clots, which may damage tissue or even lead to a stroke.
People with sickle cell anemia may also experience pain in their joints.
G
Transcribed Image Text:Case Study: DNA, Proteins, and Sickle Cell Sickle cell is a disease where a person has abnormally shaped blood cells. The reason for the abnormal shape of blood lies in the underlying genetic code. The sequence below shows a part of the genetic code for the HBB Gene. This gene provides the instructions for making a protein called beta-globin. The gene sequence is shown below. Use the sequence to create RNA and the sequence of amino acids. DNA of HbA - hemoglobin in normal adults DNA 3'to 5' RNA Amino Acid Name lexic Galbirat DNA CAC GTG GAC TGA биокас RNA Amino Acid Polypeptide chain B chain. Ⓡ9 GGA сивасикси DNA of HbS- hemoglobin found in individuals with sickle cell anemia Each amino acid in the chain joins together and then folds into a three dimensional shape - a PROTEIN. In most people, that protein is fully functional and results in blood cells that have a round shape and can bind with oxygen efficiently. What would happen if one small change occurs? Hemoglobin CTT CTC GAA GAG CAC GTG GAC TGA GGA CAT Developed by: https://www.biologycorner.com/ CTC The change in the sequence of HbS causes the blood cells to be shaped like sausages, rather than round. These cells cannot bind oxygen as efficiently and become clogged in tiny capillaries. The result is a person who is ANEMIC, or has low amounts of oxygen in their blood, which will make a person feel tired. The abnormal cells can become clumped together causing blood clots, which may damage tissue or even lead to a stroke. People with sickle cell anemia may also experience pain in their joints. G
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