type Kinase A activates mitosis type CDKI inactivates mitosis type Kinase A can inactivate CDKi Inhibits CDKi Mitosis inase A G2 G1 S-phase ould you expect these mutations in CDKI that lead to cancer to be dominant or recessive at the cellular level? Explain your thinking. a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of cion)? Explain.
type Kinase A activates mitosis type CDKI inactivates mitosis type Kinase A can inactivate CDKi Inhibits CDKi Mitosis inase A G2 G1 S-phase ould you expect these mutations in CDKI that lead to cancer to be dominant or recessive at the cellular level? Explain your thinking. a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of cion)? Explain.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Short Answer 2. You are studying the role of Kinase A and CDKI in neuroblastoma, a type of cancer. In neuroblastoma tumors, mutations are found in genes for
both Kinase A and CDKI. CDKi is a cell cycle inhibitor, and phosphorylation of CDKi by Kinase A will inhibit the normal function of CDKi, as diagrammed below.
Wild type Kinase A activates mitosis
Wild type CDKi inactivates mitosis
Wild type Kinase A can inactivate CDKi
= Inhibits
CDKi
I
Mitosis
S-phase
A) Would you expect these mutations in CDKi that lead to cancer to be dominant or recessive at the cellular level? Explain your thinking.
B) If a tumor-promoting mutation in the gene that codes for Kinase A generates an always active Kinase A protein, what type of mutation (gain of function or loss of
function)? Explain.
Kinase A
G2
G1
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