Two phenotypically normal parents produce an abnormal son in which chromosome 14 ismissing part of its short arm but has a piece of chromosome 21 attached to it. The child alsohas one normal copy of chromosome 14 and two normal copies of chromosome 21.(i)With regard to chromosome 14 and 21, what do you think are the chromosomalcompositions of the parent?(ii)Draw the pairing of the translocated chromosomes in the parent during meiosis andname the segregation pattern that contributes to the abnormal karyotype.(iii)State the syndrome and write the notation for this child's karyotype.

Translocations are chromosomal rearrangements caused by the exchange of components between two…

Answered: Two phenotypically normal parents…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

When a single recombination event occurs between a normal chromosome and a chromosome with a paracentric inversion and within the inverted region, what are the expected meiotic products?
The karyotype of a young girl who is affected with Down syndrome revealed that she has 46 chromosomes. Her phenotypically normal older brother's karyotype revealed that he has 45 chromosomes. (a) Propose an explanantion for the chromosome number in both children (b) What would you expect the chromosome number of the parents of these two children?
In a turtle species, a diploid cell in the G1 phase of the cell cycle contains 22 picograms of DNA (picogram is a measure of the total mass of the DNA present). How much DNA is present in a cell of the same species at prophase II of meiosis (prophase of the second meiotic division)?
Two phenotypically unaffected parents produce two children withfamilial Down syndrome. With regard to chromosomes 14 and 21,what are the chromosomal compositions of the parents?
In fruit flies, chromosomal crossing over does not occur in meiosis in males, whereas crossing over does occur in meiosis in females. In fruit flies that are heterozygous at many genes (i.e. many maternal and paternal versions of the genes differ), at what stage would cells no longer be heterozygous for any gene during the process of meiosis? a)After the second meiotic division in males, and after the first meiotic division in females. b)After the second meiotic division in both males and females. c)After the first meiotic division in both males and females. d)After the first meiotic division in males, and after the second meiotic division in females.
A male Drosophila from a wild-type stock is discovered to have only 7 chromosomes, whereas normally 2n = 8. Close examination reveals that one member of chromosome IV (the smallest chromosome) is attached to (translocated to) the distal end of chromosome II and is missing its centromere, thus accounting for the reduction in chromosome number. (a) Diagram all members of chromosomes II and IV in the male fly during synapsis in meiosis I. b) If this male mates with a female with normal chromosomes composition, what chromosomes compositions will occur in their progeny? Describe the type of chromosomal aberration that may occur in their progeny and indicate chromosome number for each progeny produced.
(a) A person with Down syndrome. She has 47 chromosomes rather than the common number of 46, because she has an extra copy of chromosome 21. (b) A wheat plant. Cultivated wheat is derived from the contributions of threewild species with two sets of chromosomes each, producing an organismwith six sets of chromosomes.Do these examples constitute variation in chromosomestructure or variation in chromosome number?
Assume that the diploid number of a certain species is four chromosomes, two large and two small (2n=4). a) Of the following figures, which represents a 3n (triploid) cell in mitotic metaphase? b) For each of the wrong answers from part (a) above, explain briefly why it cannot represent a triploid cell in mitotic metaphase.

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