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Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН

Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН
Transcribed Image Text:Tobacco smoke from a typical cigarette contains 20-40 ng of benzo[a]pyrene, which can be oxidized by mammalian metabolic enzymes to form cancerogenic and mutagenic compound A. Carcinogenic properties of compound A arise from its ability to react with 2-amino group of guanine base, an essential component of DNA, according to the following scheme. Propose the structure of compound A indicating the stereochemistry where appropriate. DNA NH DNA-NH2 НО, HO Compound A OH HO ОН HO ОН
NH2 HO, HO" Он HO ОН
Transcribed Image Text:NH2 HO, HO" Он HO ОН
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