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To break up a clot: 1) fibrinogen is converted to fibrin 2) plasmin is converted to plasminogen 3) fibrin is cleaved 4) tPA cleaves plasmin

To break up a clot: 1) fibrinogen is converted to fibrin 2) plasmin is converted to plasminogen 3) fibrin is cleaved 4) tPA cleaves plasmin

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### How Clot-Breaking Mechanisms Work To break up a clot: 1. **Fibrinogen is converted to fibrin** - This is a crucial step in the clotting process, rather than breaking up a clot. 2. **Plasmin is converted to plasminogen** - This is incorrect; it is the other way around. Plasminogen is converted to plasmin, which is an important enzyme in breaking down clots. 3. **Fibrin is cleaved** - Correct. The cleavage of fibrin is essential in breaking down the clot structure. Fibrin forms the mesh that stabilizes a blood clot, and its breakdown is crucial for clot resolution. 4. **tPA cleaves plasmin** - This is partially correct. Tissue plasminogen activator (tPA) actually converts plasminogen to plasmin, which then cleaves fibrin and breaks the clot. Understanding these steps is important for both medical professionals and students learning about hematology and clot management.
Transcribed Image Text:### How Clot-Breaking Mechanisms Work To break up a clot: 1. **Fibrinogen is converted to fibrin** - This is a crucial step in the clotting process, rather than breaking up a clot. 2. **Plasmin is converted to plasminogen** - This is incorrect; it is the other way around. Plasminogen is converted to plasmin, which is an important enzyme in breaking down clots. 3. **Fibrin is cleaved** - Correct. The cleavage of fibrin is essential in breaking down the clot structure. Fibrin forms the mesh that stabilizes a blood clot, and its breakdown is crucial for clot resolution. 4. **tPA cleaves plasmin** - This is partially correct. Tissue plasminogen activator (tPA) actually converts plasminogen to plasmin, which then cleaves fibrin and breaks the clot. Understanding these steps is important for both medical professionals and students learning about hematology and clot management.
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