This is a design of synthetic platelets. Explains about the desgin of synthetic platelets and the role This image represents a schematic of a nanoparticle structure featuring three distinct components, as indicated in the accompanying key:1. **PLGA-PLL (Poly(lactic-co-glycolic acid)-poly(L-lysine))**: Illustrated as a large central sphere in green, this serves as the core of the nanoparticle. PLGA-PLL is a biocompatible and biodegradable polymer used in drug delivery systems, providing stability and aiding in controlled release.2. **PEG (Polyethylene Glycol)**: Depicted as wavy green lines extending outward from the core, PEG is used to enhance the nanoparticle's solubility and circulation time in the bloodstream. It helps minimize immune detection and increases the biocompatibility of the structure.3. **RGD Moiety**: Shown as blue hexagonal shapes at the end of the PEG chains, RGD moieties are peptide sequences that facilitate specific binding to cell membrane receptors. This targeting capability can improve the delivery of therapeutic agents precisely to desired cells.The diagram effectively portrays the integration of these components into a composite nanoparticle designed for targeted drug delivery, highlighting the synergy between structural stability, biocompatibility, and targeting precision.

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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This is a design of synthetic platelets. Explains about the desgin of synthetic platelets and the role

This image represents a schematic of a nanoparticle structure featuring three distinct components, as indicated in the accompanying key:

1. **PLGA-PLL (Poly(lactic-co-glycolic acid)-poly(L-lysine))**: Illustrated as a large central sphere in green, this serves as the core of the nanoparticle. PLGA-PLL is a biocompatible and biodegradable polymer used in drug delivery systems, providing stability and aiding in controlled release.

2. **PEG (Polyethylene Glycol)**: Depicted as wavy green lines extending outward from the core, PEG is used to enhance the nanoparticle's solubility and circulation time in the bloodstream. It helps minimize immune detection and increases the biocompatibility of the structure.

3. **RGD Moiety**: Shown as blue hexagonal shapes at the end of the PEG chains, RGD moieties are peptide sequences that facilitate specific binding to cell membrane receptors. This targeting capability can improve the delivery of therapeutic agents precisely to desired cells.

The diagram effectively portrays the integration of these components into a composite nanoparticle designed for targeted drug delivery, highlighting the synergy between structural stability, biocompatibility, and targeting precision.

Expert Solution

Step 1: Introduce- Few important points

Blood: It is a connective tissue composed of a liquid extracellular matrix called blood plasma.

Functions of blood :

Helps in the transportation of oxygen, carbon dioxide, nutrients, hormones, and wastes.
It helps in the regulation of pH, body temperature, and water content of cells.
Protection against blood loss through clotting and against disease through phagocytic activity with blood cells and antibodies.

Platelets: They are blood components that allow blood to stop excessive bleeding. Their granules also contain chemicals.

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